WEKO3
アイテム
The molecular biology of lung cancer brain metastasis : an overview of current comprehensions and future perspectives
https://tokushima-u.repo.nii.ac.jp/records/2002808
https://tokushima-u.repo.nii.ac.jp/records/200280856a4702d-f639-4699-9363-c7ecca1c5a20
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201604195004.pdf (338 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2016-04-19 | |||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | The molecular biology of lung cancer brain metastasis : an overview of current comprehensions and future perspectives | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 著者 |
埴淵, 昌毅
× 埴淵, 昌毅
WEKO
1563
× Kim, Sun-Jin
× Fidler, Isaiah J.
× 西岡, 安彦
WEKO
1542
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| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Brain metastases occur in 20-40% of patients with advanced malignancies and lung cancer is one of the most common causes of brain metastases. The occurrence of brain metastases is associated with poor prognosis and high morbidity in patients with advanced lung cancer, even after intensive multimodal therapy. Progress in treating brain metastases has been hampered by a lack of model systems, a lack of human tissue samples, and the exclusion of brain metastatic patients from many clinical trials. While the biology of brain metastasis is still poorly understood, it is encouraging to see more efforts are beginning to be directed toward the study of brain metastasis. During the multi-step process of metastasis, functional significance of gene expressions, changes in brain vasculature, abnormal secretion of soluble factors and activation of autocrine/paracrine signaling are considered to contribute to the brain metastasis development. A better understanding of the mechanism of this disease will help us to identify the appropriate therapeutic strategies, which leads to circumvent brain metastases. Recent findings on the biology of lung cancer brain metastases and translational leads identified by molecular studies are discussed in this review. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | brain metastasis | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | lung cancer | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | molecular biology | |||||||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 61, 号 3-4, p. 241-253, 発行日 2014-08 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||
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| 識別子 | 297601 | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
