| Item type |
文献 / Documents(1) |
| 公開日 |
2016-02-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
http://www.sciencedirect.com/science/article/pii/S0006291X09015770 |
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関連名称 |
10.1016/j.bbrc.2009.08.024 |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
YKL-40 secreted from adipose tissue inhibits degradation of type I collagen |
| 著者 |
岩田, 武男
クワジマ, マサミチ
スケノ, アキコ
石丸, 直澄
林, 良夫
Wabitsch, Martin
水澤, 典子
板倉, 光夫
吉本, 勝彦
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| 抄録 |
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内容記述 |
Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF cells in human visceral AT. YKL-40 expression levels in SVF cells from visceral AT were higher than in those from subcutaneous AT. Immunofluorescence staining revealed that YKL-40 was exclusively expressed in macrophages among SVF cells. YKL-40 purified from SVF cells inhibited the degradation of type I collagen, a major extracellular matrix of AT, by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen. The expression of MMP-1 in preadipocytes and macrophages was enhanced by interaction between these cells. These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation. |
| キーワード |
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|
主題 |
YKL-40 |
| キーワード |
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|
主題 |
MMP-1 |
| キーワード |
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|
主題 |
type I collagen |
| キーワード |
|
|
主題 |
adipose tissue |
| キーワード |
|
|
主題 |
macrophage |
| キーワード |
|
|
主題 |
preadipocyte |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 388,
号 3,
p. 511-516,
発行日 2009-10-23
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006291X |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 権利情報 |
|
|
権利情報 |
© 2009 Elsevier Inc. All rights reserved.© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license |
| EID |
|
|
識別子 |
210920 |
| 言語 |
|
|
言語 |
eng |
LID201602262002.pdf (1.03 MB)
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