| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2016-02-29 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1007/s12022-009-9076-0 |
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関連名称 |
10.1007/s12022-009-9076-0 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Expression of p18INK4C is down-regulated in human pituitary adenomas |
| タイトル別表記 |
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その他のタイトル |
Role of p18INK4C in pituitary tumorigenesis |
| 著者 |
Hossain, Md. Golam
岩田, 武男
WEKO
1264
e-Rad_Researcher
10350399
| ja |
岩田, 武男
岩田, 武男
ISNI
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| ja-Kana |
イワタ, タケオ
イワタ, タケオ
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| en |
Iwata, Takeo
Iwata, Takeo
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Search repository
水澤, 典子
Qian, Zhi Rong
Wan, Shahidan
Shima, Nazatul
オクツ, トオル
ヤマダ, ショウゾウ
佐野, 壽昭
吉本, 勝彦
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| 抄録 |
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内容記述 |
Cyclin-dependent kinase inhibitors represented by the INK4 family comprising p16INK4A, p15INK4B, p18INK4C, and p19INK4D are regulators of the cell cycle shown to be aberrant in many types of cancer. Mice lacking p18Ink4c exhibit a series of phenotypes including the development of widespread organomegaly and pituitary adenomas. The objective of our study is to examine the role of p18INK4C in the pathogenesis of human pituitary tumors. The protein and mRNA levels of p18INK4C were examined by immunohistochemistry and real-time reverse transcription-polymerase chain reaction, respectively. The methylation status of the p18INK4C gene promoter and somatic mutations of the p18INK4C gene were also investigated. p18INK4C protein expression was lost or significantly reduced in 64% of pituitary adenomas compared with levels in normal pituitary glands. p18INK4C mRNA levels were low in all ACTH adenomas and non-functioning (NF)-FSH and in 42%, 70% and 66% of GH, PRL, and subtype 3 adenomas, respectively. p18INK4C mRNA levels were significantly associated with p18INK4C protein levels. Neither methylated promoters in pituitary adenomas, except in 1 NF-FSH adenoma, nor somatic mutations of the p18INK4C gene in any pituitary adenomas were detected. The down-regulation of p18INK4C expression may contribute to the tumorigenesis of pituitary adenomas. |
| キーワード |
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主題 |
p18INK4C gene |
| キーワード |
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主題 |
INK4 family proteins |
| キーワード |
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主題 |
pituitary adenomas |
| キーワード |
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主題 |
cell cycle regulators |
| キーワード |
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主題 |
DNA methylation |
| 書誌情報 |
en : Endocrine Pathology
巻 20,
号 2,
p. 114-121,
発行日 2009-04-29
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10463976 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
15590097 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10803175 |
| 出版者 |
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出版者 |
Humana Press |
| 権利情報 |
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権利情報 |
© Humana Press Inc. 2009
The final publication is available at Springer via http://dx.doi.org/10.1007/s12022-009-9076-0. |
| EID |
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識別子 |
212956 |
| 言語 |
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言語 |
eng |
LID201602262006.pdf (3 MB)
