| Item type |
文献 / Documents(1) |
| 公開日 |
2016-02-29 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
http://www.jci.org/articles/view/2992/version/1/pdf/render |
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関連名称 |
10.1172/JCI2992 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Abrogation of Autoimmune Diabetes in Nonobese Diabetic Mice and Protection against Effector Lymphocytes by Transgenic Paracrine TGF-β1 |
| 著者 |
モリタニ, マキ
吉本, 勝彦
Wong, Susan F.
(田中)小杉, 知里
ヤマオカ, タカシ
佐野, 壽昭
コマガタ, ヨシノリ
ミヤザキ, ジュンイチ
キクタニ, ヒトシ
板倉, 光夫
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| 抄録 |
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内容記述 |
Paracrine effect of transforming growth factor-β1 (TGF-β1) on autoimmune insulitis and diabetes was studied by transgenic production of the active form of porcine TGF-β1 (pTGF-β1) in pancreatic islet (islet) α cells in nonobese diabetic (NOD) mice under the control of rat glucagon promoter (RGP) (NOD-RGP-TGF-β1). None of 27 NOD-RGP-TGF-β1 mice developed diabetes by 45 wk of age, in contrast to 40 and 71% in male and female nontransgenic mice, respectively. None of the NOD-RGP-TGF-β1 mice developed diabetes after cyclophosphamide (CY) administration. Adoptive transfer of splenocytes of NOD-RGP-TGF-β1 mice to neonatal NOD mice did not transfer diabetes after CY administration. Adoptive transfer of three types of diabetogenic lymphocytes to NOD-RGP-TGF-β1 and nontransgenic mice after CY administration led to the lower incidence of diabetes in NOD-RGP-TGF-β1 mice versus that in nontransgenic mice: 29 vs. 77% for diabetogenic splenocytes, 25 vs. 75% for islet β cell–specific Th1 clone cells, and 0 vs. 50% for islet β cell–specific CD8+ clone cells, respectively. Based on these, it is concluded that autoimmune diabetes in NOD mice is not a systemic disease and it can be completely prevented by the paracrine TGF-β1 in the islet compartment through protection against CD4+ and CD8+ effector lymphocytes. |
| キーワード |
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|
主題 |
nonobese diabetic (NOD) mice |
| キーワード |
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|
主題 |
pancreatic islets |
| キーワード |
|
|
主題 |
rat glucagon promoter (RGP) |
| キーワード |
|
|
主題 |
adoptive transfer |
| キーワード |
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|
主題 |
CD4+ and CD8+ T cells |
| 書誌情報 |
en : Journal of Clinical Investigation
巻 102,
号 3,
p. 499-506,
発行日 1998-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00219738 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00695520 |
| 権利情報 |
|
|
権利情報 |
© The American Society for Clinical Investigation, Inc. |
| EID |
|
|
識別子 |
72187 |
| 言語 |
|
|
言語 |
eng |
LID201602262001.pdf (416 KB)
