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Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model
https://tokushima-u.repo.nii.ac.jp/records/2002977
https://tokushima-u.repo.nii.ac.jp/records/200297784eb0137-f91d-434c-b9fd-c90ebede0c7c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201607122001.pdf (2.58 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2016-07-12 | |||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||
| 関連識別子 | http://downloads.hindawi.com/journals/omcl/2016/5679040.pdf | |||||||||||||||||||
| 言語 | ja | |||||||||||||||||||
| 関連名称 | 10.1155/2016/5679040 | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 著者 |
玉木, 直文
× 玉木, 直文× Orihuela-Campos, Rita Cristina
× 福井, 誠
WEKO
1720
× 伊藤, 博夫
WEKO
203
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed.The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway.The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses. | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : Oxidative Medicine and Cellular Longevity 巻 2016, p. 5679040, 発行日 2016 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 19420900 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA12489832 | |||||||||||||||||||
| 権利情報 | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 権利情報 | Copyright © 2016 Naofumi Tamaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||
| EID | ||||||||||||||||||||
| 識別子 | 330044 | |||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
