WEKO3
アイテム
自閉症の脳画像研究
https://tokushima-u.repo.nii.ac.jp/records/2002981
https://tokushima-u.repo.nii.ac.jp/records/2002981ac7b067f-a0fa-48af-a733-92df79a4c475
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201607152003.pdf (920 KB)
|
|
| Item type | 文献 / Documents(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2016-07-15 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 自閉症の脳画像研究 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | ジヘイショウ ノ ノウガゾウ ケンキュウ | |||||||||||
| 言語 | ja-Kana | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Neuroimaging study of autism | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
森, 健治
× 森, 健治
WEKO
1564
|
|||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Brothers proposed a network of neural regions that comprise the “social brain”, which includes the amygdala, the orbito-frontal cortex, and the superior temporal sulcus and gyrus. Since the psychiatric condition of autism involves deficits in “social intelligence”, it is plausible that autism may be caused by an abnormality of these regions. We measured chemical metabolites in the left amygdala and the bilateral orbito-frontal cortex, which are the main components of the social brain. We also examined the association between these metabolic findings and social abilities in subjects with autism. The study group included 77 autistic patients and age-matched 31 normal children. Conventional proton magnetic resonance spectra were obtained using the STEAM sequence with parameters of TR＝5 sec and TE＝15 msec by a 1.5-tesla clinical MRI system. We analyzed the concentrations of N-acetylaspartate （NAA）, creatine/phosphocreatine （Cr）, and choline-containing compounds （Cho） using LCModel （Ver.6.1）. The concentrations of NAA in the left amygdala and the bilateral orbito-frontal cortex in autistic patients were significantly decreased compared to those in the control group. In the autistic patients, the NAA concentrations in these regions correlated with their social quotient. These findings suggest the presence of neuronal dysfunction in the amygdala and orbito-frontal cortex in autism. The amygdala is thought to play a central role in associating sensory cues with their motivational and emotional significance. Schoenbaum et al. proposed models of amygdala-frontal interaction in which motivational and emotional significance, coded by the amygdala, is conveyed to the orbito-frontal cortex for the control of action. Dysfunction in the amygdala and orbito-frontal cortex may contribute to the pathogenesis of autism. |
|||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | autism | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | proton magnetic resonance spectroscopy （1H-MRS） | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | amygdala | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | orbito-frontal cortex | |||||||||||
| 書誌情報 |
ja : 四国医学雑誌 巻 70, 号 1-2, p. 25-30, 発行日 2014-04-25 |
|||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 00373699 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00102041 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 徳島医学会 | |||||||||||
| 言語 | ja | |||||||||||
| EID | ||||||||||||
| 識別子 | 300962 | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
