| Item type |
文献 / Documents(1) |
| 公開日 |
2017-01-24 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1038/jhg.2016.82 |
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関連名称 |
10.1038/jhg.2016.82 |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men |
| タイトル別表記 |
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その他のタイトル |
Candidate polymorphism associated with FSH levels |
| 著者 |
佐藤, 陽一
田嶋, 敦
カツラヤマ, モトキ
ノザワ, シアリ
ヨシイケ, ミキ
Koh, Eitetsue
カナヤ, ジロウ
ナミキ, ミキオ
マツミヤ, キヨミ
ツジムラ, アキラ
コマツ, キヨシ
イトウ, ナオキ
エグチ, ジロウ
井本, 逸勢
山内, あい子
イワモト, テルアキ
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| 抄録 |
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内容記述 |
In men, follicle-stimulating hormone (FSH) acts on the seminiferous tubules and enhances spermatogenesis. Recently, a candidate locus (rs2414095) for FSH levels was identified by a genome-wide association study (GWAS) in Chinese men. The rs2414095 SNP is found on the third intron of the cytochrome P450, family 19, subfamily A, peptide 1 (CYP19A1) gene encoding an aromatase. In the present study, we performed a replication study in 1687 Japanese men (901 from cohort 1 and 786 from cohort 2) to assess whether this single nucleotide polymorphism (SNP) is associated with circulating FSH levels. Furthermore, we investigated whether the rs2414095 SNP is correlated with semen quality traits in 2015 Japanese men (1224 from cohort 1 and 791 from cohort 2). The rs2414095 SNP was significantly associated with circulating FSH levels (βSTD = 0.15, P = 9.7 × 10-5), sperm concentration (βSTD = 0.073, P = 0.032), and total sperm number (TSN) (βSTD = 0.074, P = 0.027) in a combined analysis of the two Japanese male cohorts. We successfully replicated, in Japanese men, the results of the previous GWAS for the rs2414095 SNP in Chinese men, and found that the rs2414095 SNP was related with sperm production. |
| 書誌情報 |
en : Journal of Human Genetics
巻 61,
号 11,
p. 911-915,
発行日 2016-11
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14345161 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11206160 |
| 備考 |
|
|
値 |
論文本文 : LID201701242001.pdf
Table 1 : LID201701242002.pdf
Table 2 : LID201701242003.pdf
Table 3 : LID201701242004.pdf |
| 権利情報 |
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|
権利情報 |
© 2016 The Japan Society of Human Genetics |
| EID |
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識別子 |
313471 |
| 言語 |
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言語 |
eng |
LID201701242001.pdf (104 KB)
