WEKO3
アイテム
Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1
https://tokushima-u.repo.nii.ac.jp/records/2003255
https://tokushima-u.repo.nii.ac.jp/records/20032554aba7fa5-ed2e-4faa-8a03-e86b5cfb70ba
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201704072001.pdf (2.05 MB)
|
|
| Item type | 文献 / Documents(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-04-07 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.2174/0929866523666160204124406 | |||||||||||||||||
| 関連名称 | 10.2174/0929866523666160204124406 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1 | |||||||||||||||||
| タイトル別表記 | ||||||||||||||||||
| その他のタイトル | Mechanism of a Mutation in Non-Structural Protein 1 Including High Pathogenicity of Avian Influenza Virus H5N1 | |||||||||||||||||
| 著者 |
加藤, 有介
× 加藤, 有介× 福井, 清
WEKO
271
× 鈴木, 和男
|
|||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述 | Avian influenza H5N1 has shown high mortality rate in human. Non-structural protein 1 (NS1) is a virulence factor of H5N1. Mutation at the 42nd residue within the RNA-binding domain (RBD) of NS1 dramatically changes the degree of pathogenicity of H5N1 in mice. We here studied the impact of this mutation on the function of RBD, and found that RBD with serine at the 42th residue binds doublestranded RNA (dsRNA), whereas that with proline at the 42th residue does not. Analysis of structural models of the RBD proteins with S42 and P42 suggested remarkable difference in the structure of the dsRNA-binding interface, whereas structural analysis by analytical gel filtration and CD measurements did not indicate difference between those RBD proteins. Our results suggest that the single amino acid replacement induces a minor, but global structural change leading to the loss of function of NS1 thereby the change in the degree of pathogenicity. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | avian Influenza | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | non-structural protein 1 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | structure modeling | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | cytokine storm | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | double-stranded RNA | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | interaction | |||||||||||||||||
| 書誌情報 |
en : Protein and Peptide Letters 巻 23, 号 4, p. 372-378, 発行日 2016 |
|||||||||||||||||
| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 09298665 | |||||||||||||||||
| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA1102463X | |||||||||||||||||
| 備考 | ||||||||||||||||||
| 値 | Running Title : NS1 Mechanism of High Pathogenicity of H5N1 The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/0929866523666160204124406. |
|||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 311902 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
