| Item type |
文献 / Documents(1) |
| 公開日 |
2017-06-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.18632/oncotarget.7937 |
|
|
関連名称 |
10.18632/oncotarget.7937 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma. |
| 著者 |
ハマダ, ジュンイチ
ショウダ, カツトシ
増田, 清士
フジタ, ユウジ
成戸, 卓也
コウモト, トモヒロ
ミヤカミ, ユウコ
ワタナベ, ミキ
工藤, 保誠
フジワラ, ヒトシ
イチカワ, ダイスケ
オオツジ, エイゴ
井本, 逸勢
|
| 抄録 |
|
|
内容記述 |
T-cell intracellular antigen-1 (TIA1) is an RNA-binding protein involved in many regulatory aspects of mRNA metabolism. Here, we report previously unknown tumor-promoting activity of TIA1, which seems to be associated with its isoform-specific molecular distribution and regulation of a set of cancer-related transcripts, in esophageal squamous cell carcinoma (ESCC). Immunohistochemical overexpression of TIA1 ectopically localized in the cytoplasm of tumor cells was an independent prognosticator for worse overall survival in a cohort of 143 ESCC patients. Knockdown of TIA1 inhibited proliferation of ESCC cells. By exogenously introducing each of two major isoforms, TIA1a and TIA1b, only TIA1a, which was localized to both the nucleus and cytoplasm, promoted anchorage-dependent and anchorage-independent ESCC cell proliferation. Ribonucleoprotein immunoprecipitation, followed by microarray analysis or massive-parallel sequencing, identified a set of TIA1-binding mRNAs, including SKP2 and CCNA2. TIA1 increased SKP2 and CCNA2 protein levels through the suppression of mRNA decay and translational induction, respectively. Our findings uncover a novel oncogenic function of TIA1 in esophageal tumorigenesis, and implicate its use as a marker for prognostic evaluation and as a therapeutic target in ESCC. |
| キーワード |
|
|
主題 |
T-cell intracellular antigen-1 |
| キーワード |
|
|
主題 |
isoform |
| キーワード |
|
|
主題 |
oncogene |
| キーワード |
|
|
主題 |
RNA-binding protein |
| キーワード |
|
|
主題 |
esophageal squamous cell carcinoma |
| 書誌情報 |
en : Oncotarget
巻 7,
号 13,
p. 17111-17128,
発行日 2016-03-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19492553 |
| 権利情報 |
|
|
権利情報 |
Copyright: © 2016 Masuda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source arecredited. |
| EID |
|
|
識別子 |
310110 |
| 言語 |
|
|
言語 |
eng |
LID201705314001.pdf (9.46 MB)
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