| Item type |
文献 / Documents(1) |
| 公開日 |
2017-11-16 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The role of cyclosporin A on antibody-dependent monocytemediated cytotoxicity against human multidrug-resistant cancer cells |
|
言語 |
en |
| 著者 |
矢野, 聖二
楊河, 宏章
埴淵, 昌毅
Pai, Kalpana
西岡, 安彦
ツルオ, タカシ
曽根, 三郎
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A P-glycoprotein (P-gp) inhibitor, cyclosporin A (CsA) was found to enhance the susceptibility of multidrug resistant (MDR) cancer cells to anti-P-gp antibody-dependent cellular cytolysis (ADCC) by monocytes, but the exact mechanism is unknown. In this study, we examined whether CsA enhanced the susceptibility of MDR cells through its inhibitory effect of P-gp function by using anti-ganglioside GM2 (GM2) monoclonal antibody (Ab), KM966, instead of anti-P-gp Ab, MRK16. Monocyte-ADCC induced by both KM966 and MRK16 against P-gp positive human MDR ovarian cancer cells was significantly augmented by addition of CsA. KM966, but not MRK16, induced monocyte-ADCC against P-gp negative human ovarian cancer cells and CsA enhanced this ADCC activity, indicating that suppressive effect of P-gp function by CsA was not essential to the enhancement of ADCC. Moreover, pretreatment of tumor cells with CsA augmented their susceptibility to monocyte-ADCC irrespective of P-gp expression. Interestingly, KM966 or MRK16 induced monocyte-ADCC against various human lung cancer cells expressing either GM2 or P-gp, but CsA did not affect these ADCC. These findings suggest that CsA may enhance the susceptibility to the monocyte-ADCC of ovarian cancer cells, but not of lung cancer cells, irrespective of its suppressive effect of P-gp function. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
multidrug resistance |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
P-glycoprotein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ganglioside GM2 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ADCC |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cyclosporin A |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 44,
号 3-4,
p. 185-191,
発行日 1998
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
146318 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_44_3-4_185.pdf (249 KB)
