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The role of caspase cascade on the development of primary Sjögren's syndrome
https://tokushima-u.repo.nii.ac.jp/records/2003872
https://tokushima-u.repo.nii.ac.jp/records/20038728f60f3fa-7cad-4235-9416-a88bfe9b7bb1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_50_1-2_32.pdf (76 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2017-11-22 | |||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | The role of caspase cascade on the development of primary Sjögren's syndrome | |||||||||||||||||
| 著者 |
林, 良夫
× 林, 良夫
WEKO
1659
× 新垣, 理恵子× 石丸, 直澄
WEKO
1721
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| 内容記述 | Primary Sjögren syndrome (SS) is an autoimmune disease characterized by diffuse lymphoid cell infiltrates in the salivary and lacrimal glands, resulting in symptoms of dry eye and dry mouth due to insufficient secretion. Previously, we have identified the120 kDa α-fodrin as an important autoantigen on the development of SS in both animal model and SS patients, but the mechanism of α-fodrin cleavage leading to tissue destruction in SS remains unclear. In murine primary SS model, tissue-infiltrating CD4+ T cells purified from the salivary glands bear a large proportion of Fas ligand (FasL), and the salivary gland duct cells constitutively possess Fas. Infiltrating CD4+ T cells identified significant51Cr release against mouse salivary gland (MSG) cells. In vitro studies demonstrated that apoptotic MSG cells result in a specific α-fodrin cleavage into 120 kDa, and preincubation with caspase-inhibitor peptides blocked α-fodrin cleavage. The treatment with caspase-inhibitors in vivo prevented the development of autoimmune lesions in the salivary and lacrimal glands. Thus, an increased activity in caspase cascade may be involved in the progression of α-fodrin proteolysis and tissue destruction on the development of SS. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Sjögren’s syndrome | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | autoantigen | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | caspase | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | apoptosis | |||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 50, 号 1-2, p. 32-38, 発行日 2003 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 100464 | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
