| Item type |
文献 / Documents(1) |
| 公開日 |
2017-11-21 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Clinical value of the determination of serum guanase activity in patients with chronic hepatitis type C |
|
言語 |
en |
| 著者 |
マツナガ, ヒロコ
本田, 浩仁
久保, 謙一郎
サンノミヤ, カツタカ
Cui, Xuezhi
トヨタ, ヨシオ
モリ, トシフミ
六車, 直樹
岡久, 稔也
岡村, 誠介
清水, 一郎
伊東, 進
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The study examines the clinical significance of guanase (GU) measurement inpatients with hepatitis C. 688 patients in whom either ALT was abnormal, or in whom HBsAg or HCVAb was detected in the serum, were enrolled into this study. The percentage of cases in which normal ALT while elevated GU was compared among the different disease groups. Then, the percentage of cases with normal ALT but elevated GU was compared between HBV and HCV groups. For the entire population, a significant correlation was observed between ALT and GU (r=0.872). The overall percentage of cases with normal ALT but elevated GU activity was 11.4%. In HCV group, 449 cases had normal ALT. Of these cases, 20.3% had elevated GU, while ALT was normal. Before 1989, no test to check donated blood for HCV antibody was available. However, screening of donated blood for high GU was associated with a reduced incidence of post-transfusion hepatitis. This is probably because following the screening, blood donated by patients with hepatitis C who had normal ALT but elevated GU was rejected. After the introduction of HCV antibody measurement, GU measurement is still useful to reveal the pathophysiological condition in-patients with chronic hepatitis type C. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chronic hepatitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HCV |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
guanase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ALT |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 50,
号 1-2,
p. 64-71,
発行日 2003
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
94267 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_50_1-2_64.pdf (76.2 KB)
