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Multidrug resistance in hematological malignancy
https://tokushima-u.repo.nii.ac.jp/records/2003884
https://tokushima-u.repo.nii.ac.jp/records/2003884baf8bdcd-7b76-403f-941d-dcdd83143da9
| 名前 / ファイル | ライセンス | アクション |
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jmi_50_3-4_126.pdf (115 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2017-11-21 | |||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Multidrug resistance in hematological malignancy | |||||||||||||||||||
| 著者 |
廣瀬, 政雄
× 廣瀬, 政雄
× 細井, 英司
WEKO
1606
× 濱野, 修一× Jalili, Ali
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| 内容記述 | The recent treatment of hematological malignancies appears to be unsatisfactory in child and adult patients with acute myeloid leukemia and adult patients with acute lymphocytic leukemia. A major problem in the treatment of leukemia is caused by the development of drug resistance to chemotherapeutic agents, which is already present at diagnosis or after chemotherapy as a minimal residual disease, their resistance having originated from genetic or epigenetic mutations during prior growth of the leukemia clone. It was suggested that the mechanisms of drug resistance consist of drug resistance proteins, which work as a drug efflux pump. These are the permeability- related glycoprotein (P- Gp), the multidrug-resistance associated protein(MRP), the lung resistance protein(LRP), and other MDR proteins such as the transporter associated with antigen processing (TAP), anthracyclin resistance associated protein (ARA), MRP 2-7, and breast cancer resistance protein (BCRP). In addition, anti-apoptosis mechanisms, alterations of tumor suppressor genes, altered immunogenicity, drug resistance mechanisms for individual drugs, and clinical risk factors such as white blood cell count, age, and other factors have been reported to act in drug resistance singly or in combinations. Here we describe the update of research on the biology of MDR in the hematological malignancies and also discuss how to overcome MDR and adapt the updated treatment methods in the clinical medical field. | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | multidrug resistance | |||||||||||||||||||
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| 主題 | MDR | |||||||||||||||||||
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| 主題 | hematology | |||||||||||||||||||
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| 主題 | leukemia | |||||||||||||||||||
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| 主題 | lymphoma | |||||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 50, 号 3-4, p. 126-135, 発行日 2003 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||
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| 識別子 | 162210 | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
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廣瀬, 政雄, 細井, 英司, 濱野, 修一, Jalili, Ali, 2003, Multidrug resistance in hematological malignancy: 126–135 p.
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