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Angiogenesis of prostate cancer and antiangiogenic therapy
https://tokushima-u.repo.nii.ac.jp/records/2003887
https://tokushima-u.repo.nii.ac.jp/records/20038871bb7f747-7db3-4ddc-b801-5804fe16fa13
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_50_3-4_146.pdf (142 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2017-11-20 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Angiogenesis of prostate cancer and antiangiogenic therapy | |||||||||||
| 著者 |
上原, 久典
× 上原, 久典
WEKO
1548
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| 抄録 | ||||||||||||
| 内容記述 | Tumor-associated angiogenesis refers to the growth of newvessels toward and within the tumor. Several studies have revealed that increasing intratumoral microvessel density, a major of tumor-associated angiogenesis, correlates with greater aggressiveness of prostate cancer. Angiogenesis consists of multiple, sequential, and interdependent steps dependent on the local balance of proangiogenic and antiangiogenic molecules. Many proangiogenic and antiangiogenic molecules have been demonstrated to regulate growth and metastasis of prostate cancer. As tumor-associated angiogenesis is a crucial step in the process of prostate cancer development, inhibition of tumor neovascularization, and/or destruction of tumor vasculature (antiangiogenic therapy)may maintain the tumors in a dormant state or, perhaps in combination with cytotoxic therapies, potentiate shrinkage of tumors. Recently, therapeutic agents targeting the receptors of proangiogenic molecules and their signal transduction cascade have been developed. In this article, the role of angiogenic molecules in prostate cancer biology, and the application of angiogenesis inhibition to therapeutics for prostate cancer are reviewed. | |||||||||||
| キーワード | ||||||||||||
| 主題 | angiogenesis | |||||||||||
| キーワード | ||||||||||||
| 主題 | prostate cancer | |||||||||||
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| 主題 | metastasis | |||||||||||
| キーワード | ||||||||||||
| 主題 | antiangiogenic therapy | |||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 50, 号 3-4, p. 146-153, 発行日 2003 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 13431420 | |||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11166929 | |||||||||||
| EID | ||||||||||||
| 識別子 | 88516 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
