| Item type |
文献 / Documents(1) |
| 公開日 |
2017-12-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.53.70 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.53.70 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Altered allergic cytokine and antibody response in mice treated with Bisphenol A |
|
言語 |
en |
| 著者 |
Alizadeh, Mohammad
太田, 房雄
細井, 和雄
カトウ, マコト
酒井, 徹
Satter, Mohammed A.
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The Objective of this study was to elucidate if Bisphenol A (BPA) administration modulates T helper (Th) cell component of immune responses in a mouse challenged with ovalbumin (OVA), a major food antigen. BALB/c mice, (6 weeks old, female) were orally given either OVA (OVA-fed) or water (Water-fed), immunized intraperitoneally with OVA and injected with either BPA in corn oil or the vehicle alone. After subsequent 2nd immunization, serum titers of total IgE, OVA-specific IgE, IgG, IgG1 IgG2a and ability of their splenocytes for production of interferon (IFN)-γ, interleukin(IL) -4andIL-12 were examined by ELISA. Lymphocyte proliferation assay against concanavalin A (ConA) or OVA was also performed for 3H-Thymidine incorporation. In Water-fed groups, treatment with BPA resulted in lower titers of total IgE(P<0.01) and higher levels IgG2a (P<0.05) followed by a higher IFN-γ (P<0.05) and IL-12 (P<0.05) with an intact IL-4. When OVA-fed groups were examined, the compound did not change production of total and OVA-specific IgE and -IgG2a but resulted in lower production of IFN-γ (P<0.05). Also, BPA resulted in impaired lymphocyte proliferation to Con A in Water-fed groups (P<0.05) but not in tolerated animals. The findings indicate that BPA results in augmentation of Th1 immune responses but no significant effect on an established tolerance to OVA. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BPA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
food allergy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
OVA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IgE |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IgG2a |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytokines |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 53,
号 1-2,
p. 70-80,
発行日 2006-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
136921 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_53_1-2_70.pdf (238 KB)
