| Item type |
文献 / Documents(1) |
| 公開日 |
2017-12-07 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Prevention of lethal hepatic injury in Long-Evans Cinnamon (LEC) rats by D-galactosamine hydrochloride |
| 著者 |
大塚, 敏広
泉, 啓介
德永, 逸夫
後藤田, 貴子
イッポウシ, カネシゲ
滝口, 祥令
カネダ, シンヤ
佐竹, 宣法
大西, 隆仁
田代, 征記
島田, 光生
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| 抄録 |
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内容記述 |
Repeated injections of D-galactosamine hydrochloride (GalN) increase the survival rate of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson’s disease. The aim of the present study was to investigate the mechanism of GalN for prevention of spontaneous lethal hepatic injury in LEC rats. MaleLEC rats were given a single subcutaneous injection of 300mg/kg of GalN or vehicle (0.9%NaCl) at 14weeks, and killed at 28 weeks of age. Next, 6-week-old male LEC rats were given weekly subcutaneous injections of 300 mg/kg of GalN or vehicle for 3 or 12 weeks, and their hepatic 8-hydroxydeoxy-2’-guanosine (8-OHdG), glutathione peroxidase (GPX), and catalase activities were measured. None of GalN-treated rats died of hepatic injury (0/12), whereas the mortality rate of control rats given 0.9% NaCl was 17% (2/12). GalN administration for 12 weeks decreased the hepatic 8-OHdG, and GalN administration for either 3 or 12weeks increased the glutathione peroxidase activity. GalN administration increased the serum level of alanine aminotransferase, and accelerated megalocytic degeneration of the hepatocytes. GalN treatment is effective in preventing lethal hepatitis in LEC rats and decrease of oxidative DNA damage by GalN plays an important role in increase of the survival rate. |
| キーワード |
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|
主題 |
LEC rat |
| キーワード |
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|
主題 |
8-OHdG |
| キーワード |
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|
主題 |
glutathione peroxidase |
| キーワード |
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|
主題 |
D-galactosamine hydrochloride |
| キーワード |
|
|
主題 |
Wilson’s disease |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 53,
号 1-2,
p. 81-86,
発行日 2006-02
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
161350 |
| 言語 |
|
|
言語 |
eng |
jmi_53_1-2_81.pdf (94.8 KB)
