| Item type |
文献 / Documents(1) |
| 公開日 |
2017-12-07 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.2152/jmi.53.117 |
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関連名称 |
10.2152/jmi.53.117 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Expression analysis of a mouse orthologue of HSFY, a candidate for the azoospermic factor on the human Y chromosome |
| 著者 |
キノシタ, ケイゴ
新家, 利一
佐藤, 陽一
クラハシ, ヒロキ
コウワ, ヒロエ
Chen, Gang
梅野, 真由美
樋田, 一徳
キヨカゲ, エミ
ナカノ, タクロウ
伊東, 進
中堀, 豊
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| 抄録 |
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内容記述 |
Heat shock transcription factor on Y (HSFY) is located in one of three candidate regions for azoospermic factor (AZF), AZFb on the Y chromosome. We and others have already revealed that some azoospermic males are missing the regions of the Y chromosome including HSFY. Previously, we showed that murine HSFY-like sequence〔mHSFYL(RikencDNA4933413G11Rik)〕, which is the mouse orthologue of HSFY, is exclusively expressed in testis. The sequences encoding the presumed DNA-binding domain in HSFY and mHSFYL were found in other mammals such as dogs, cows and chickens. To elucidate mHSFYL expression in the testes in detail, we carried out in situ hybridization. mHSFYL was predominantly expressed in round spermatids. Furthermore, we clarified the intracellular distribution of mHSFYL inCOS1 cells with HA- or GFP-tagged proteins. Both HA-mHSFYL and GFP-mHSFYL were located in the nucleus. Our results suggest that HSFY/mHSFYL may have evolutionarily conserved functions for spermatogenesis. |
| キーワード |
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|
主題 |
HSFY |
| キーワード |
|
|
主題 |
mHSFYL |
| キーワード |
|
|
主題 |
HSF |
| キーワード |
|
|
主題 |
Y chromosome |
| キーワード |
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|
主題 |
spermatogenesis |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 53,
号 1-2,
p. 117-122,
発行日 2006-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
160586 |
| 言語 |
|
|
言語 |
eng |
jmi_53_1-2_117.pdf (263 KB)
