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Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome
https://tokushima-u.repo.nii.ac.jp/records/2003995
https://tokushima-u.repo.nii.ac.jp/records/20039956831798a-78b8-4bfe-8e98-8367da9be596
| 名前 / ファイル | ライセンス | アクション |
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jmi_53_1-2_134.pdf (166 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2017-12-07 | |||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.53.134 | |||||||||||||||||||||||||||||
| 関連名称 | 10.2152/jmi.53.134 | |||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||
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| タイトル | Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome | |||||||||||||||||||||||||||||
| 著者 |
カゲヤマ, ノリヒト
× カゲヤマ, ノリヒト
× 野村, 昌弘
× 中屋, 豊
WEKO
1577
× ワタナベ, トモノリ
× 伊東, 進 |
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| 内容記述 | It has been reported that a relationship exists between obstructive sleep apnea syndrome (OSAS) and cardiovascular and cerebrovascular diseases. To address this issue, we evaluated whether OSAS is associated with adhesion molecules and inflammatory signs, important indicators of atherosclerosis. Levels of high-sensitivity CRP(hs-CRP) and intercellular adhesionmolecule-1 (ICAM-1) were measured in 30 patients with ischemic heart disease, confirmed by coronary arteriography (IHD group). Twenty healthy volunteers without sleep apnea were used as controls (Group N). Sleeping respiratory information was collected using a portable sleep polygraph, together on information about oronasal flow, tracheal sound, chest respiration, and percutaneous oxygen saturation (SpO2) to obtain the apnea-hypopnea index (AHI). In the IHD group, 9 (30%) of the 30 patients showed evidence of OSAS [IHD(AHI≥40) group] and 21 did not [IHD(AHI<40) group]. The levels of hs-CRP and ICAM-1were significantly higher in the IHD group than in the N group (p<0.01). Moreover, the levels of hs-CRP and ICAM-1were significantly higher in the IHD(AHI≥40) group than in the IHD(AHI<40) group(p<0.01). However, after the administration of valsartan, angiotensin II receptor antagonists (ARB) to both IHD groups, the levels of hs-CRP and ICAM-1 decreased significantly in both groups. Moreover, a multivariate analysis revealed that the levels of hs-CRP and ICAM-1 were associated with the severity of sleep apnea. These findings suggest that, in OSAS the levels of hs-CRP and ICAM-1 are decreased and that the administration of ARB decreases the risk of atherosclerosis. | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | OSAS | |||||||||||||||||||||||||||||
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| 主題 | hs-CRP | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | adhesion molecule | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | valsartan | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | angiotensin II receptor antagonists (ARB) | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 主題 | atherosclerosis | |||||||||||||||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 53, 号 1-2, p. 134-139, 発行日 2006-02 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||||||||
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| 識別子 | 136628 | |||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||
