Item type |
文献 / Documents(1) |
公開日 |
2017-12-07 |
アクセス権 |
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アクセス権 |
open access |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
タイトル |
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タイトル |
Soy protein diet prevents hypermethioninemia caused by portacaval shunt in rats |
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言語 |
en |
著者 |
シモオカ, リエ
キド, ヤスヒロ
チバ, ナオコ
タナカ, ジュンコ
六反, 一仁
フロチ, ハルミ
平坂, 勝也
ニカワ, タケシ
キシ, キョウイチ
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In hepatic disorders, abnormal plasma amino acid profiles are observed. In this study, we examined whether soy protein isolate (SPI) improved plasma methionine concentration in the model animals. Portacaval shunt (PCS) increased alanine aminotransferase (ALT) activity and methionine concentration in blood of rats fed a 40% casein diet supplemented with 0.6% methionine (casein-M diet). A 40% SPI diet supplemented with 1.28% methionine (SPI-M diet), which contained the same amount of methionine as that in 40% casein-M diet, normalized plasma ALT activity and methionine level in PCS rats. These effects of a SPI diet may be due to its amino acid composition, since an amino acid mixture diet mimicking a 40% SPI-M diet was also effective to hypermethioninemia of PCS rats. To find key enzymes for the beneficial effect of soy protein, we examined effects of a 40% SPI-M or casein-M diet on the activities of three methionine-metabolizing enzymes in liver of PCS rats. A SPI-M diet stimulated only the activity of cystathionine γ-lyase, compared with a casein-M diet. A SPI diet has a preventive effect on hypermethioninemia, at least in part, by stimulating cystathionine γ-lyase activity in liver and may be used for nutritional management of liver disorders with hypermethioninemia. |
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言語 |
en |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
cystathionine γ-lyase |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
methionine |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
portacaval shunted rats |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
soy protein diet |
書誌情報 |
en : The journal of medical investigation : JMI
巻 53,
号 3-4,
p. 255-263,
発行日 2006-08
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収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13431420 |
収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11166929 |
EID |
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識別子 |
162860 |
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識別子タイプ |
URI |
言語 |
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言語 |
eng |