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Regulation of epithelial cell adhesion and repulsion : role of endocytic recycling
https://tokushima-u.repo.nii.ac.jp/records/2004030
https://tokushima-u.repo.nii.ac.jp/records/20040302225b8e5-3630-4425-9ebf-d1736481c881
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_55_1-2_9.pdf (691 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2018-01-18 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.55.9 | |||||||||||||||||
| 関連名称 | 10.2152/jmi.55.9 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Regulation of epithelial cell adhesion and repulsion : role of endocytic recycling | |||||||||||||||||
| 著者 |
西村, 範行
× 西村, 範行
× 佐々木, 卓也
WEKO
489
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| 内容記述 | A proper balance between cell adhesion and repulsion is essential for cellular morphogenesis during epithelial-mesenchymal transition and mesenchymal-epithelial transition. A number of ligand-receptor pairs including hepatocyte growth factor/scatter factor-Met and semaphorin-plexin are known to control this balance through the complex intracellular signaling pathways. Cell adhesion to other cells and extracellular matrix (ECM) is mediated by cell adhesion molecules (CAMs) and ECM receptors, respectively, which are associated with cytoskeleton through a variety of plaque proteins strengthening and/or weakening adhesion activities. Cell repulsion requires the downregulation of cell adhesion and the extensive changes in cytoskeletal dynamics. The endocytic recycling of CAMs and ECM receptors has recently emerged as an important mechanism to control the balance between cell adhesion and repulsion. Molecule interacting with CasL (MICAL) family proteins are originally identified as a plaque protein associated with ECM receptors integrins and implicated in semaphorin-plexin dependent repulsive axon guidance. We have recently shown that MICAL family protein JRAB/MICAL-L2 functions as an effector protein for Rab family small G protein Rab13 and regulates the endocytic recycling of tight junctional CAM occludin and controls the adhesion and repulsion of epithelial cells. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Rab13 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | JRAB/MICAL-L2 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | cell adhesion | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | cell repulsion | |||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 55, 号 1-2, p. 9-16, 発行日 2008-02 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||
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| 識別子 | 189955 | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
