| Item type |
文献 / Documents(1) |
| 公開日 |
2018-01-18 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.55.61 |
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|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.55.61 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
NO-1886, a lipoprotein lipase activator, attenuates contraction of rat intestinal ring preparations |
|
言語 |
en |
| 著者 |
Wu, Qishisan
原田, 永勝
ナカムラ, アキ
ヨシダ, マサアキ
馬渡, 一諭
ハットリ, アツシ
Li, Qinkai
下畑, 隆明
Yinhua
Lian, Xin
ナカノ, マサユキ
保坂, 利男
髙橋, 章
中屋, 豊
|
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Various intestinal symptoms or diseases are closely associated with intestinal motility, which may be altered by metabolic disturbances associated with diabetes and obesity. It is therefore important that drugs used in the treatment of metabolic disorders should not have any adverse effects on the intestine. In the present study, we examined whether [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (NO-1886), a lipoprotein lipase activator with anti-diabetic and/or anti-obese activity, affects stimulant-induced intestinal contractility. Administration of NO-1886 to intestinal ring preparations of ileum, rectum and colon isolated from Wistar rats attenuated or relaxed contraction induced by a high K+ environment or acetylcholine (ACh). This effect of NO-1886 was dependent on extracellular Ca2+ and intracellular myosin light chain kinase activity. Our results also showed that ACh-induced colonic contraction was significantly higher in the obese Otsuka Long-Evans Tokushima Fatty (OLETF) than in the non-obese Long-Evans Tokushima Otsuka (LETO) rats. The hypercontractility observed in the colons of OLETF rats occurred concomitantly with an elevation in muscarinic M3 ACh receptor protein levels. Administration of NO-1886 attenuated the obesity-induced hypercontractility of the colonic rings of OLETF rats. Thus, intestinal contractile system would be a novel pharmacological target of the lipoprotein lipase activator NO-1886. |
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言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
NO-1886 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intestinal contractility |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
obesity |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 55,
号 1-2,
p. 61-70,
発行日 2008-02
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
179205 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_55_1-2_61.pdf (713 KB)
