| Item type |
文献 / Documents(1) |
| 公開日 |
2017-09-21 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
http://doi.org/10.3164/jcbn.15-153 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes |
| 著者 |
カメザキ, チヒロ
ナカシマ, アミ
ヤマダ, アサコ
ウエニシ, サチコ
イシバシ, ヒロシ
シブヤ, ナツミ
ハマ, ススム
ホソイ, シンゾウ
ヤマシタ, エイジ
小暮, 健太朗
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| 抄録 |
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内容記述 |
Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro. Liposomes co-encapsulating astaxanthin and α-T showed no additive anntioxidative effect, while the actual scavenging activity of liposomes co-encapsulating astaxanthin and T3 was higher than the calculated additive activity. To clarify why this synergistic effect occurs, the most stable structure of astaxanthin in the presence of α-T or α-T3 was calculated. Only α-T3 was predicted to form hydrogen bonding with astaxanthin, and the astaxanthin polyene chain would partially interact with the α-T3 triene chain, which could explain why there was a synergistic effect between astaxanthin and T3 but not α-T. In conclusion, co-encapsulation of astaxanthin and T3 induces synergistic scavenging activity by intermolecular interactions between the two antioxidants. |
| キーワード |
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|
主題 |
astaxanthin |
| キーワード |
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|
主題 |
vitamin E |
| キーワード |
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|
主題 |
tocotrienol |
| キーワード |
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|
主題 |
intermolecular interaction |
| キーワード |
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|
主題 |
synergistic activity |
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition
巻 59,
号 2,
p. 100-106,
発行日 2016-09-01
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09120009 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18805086 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10710201 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12091064 |
| 出版者 |
|
|
出版者 |
Society for Free Radical Research Japan |
| 権利情報 |
|
|
権利情報 |
© 2016 Society for Free Radical Research Japan |
| EID |
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|
識別子 |
317555 |
| 言語 |
|
|
言語 |
eng |
jcbn_59_2_100.pdf (830 KB)
