| Item type |
文献 / Documents(1) |
| 公開日 |
2018-01-23 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.55.133 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.55.133 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages |
|
言語 |
en |
| 著者 |
Huang, Huiwei
He, Jianghong
Yuan, Ying
アオヤギ, エリコ
タケナカ, ヒデタカ
イタガキ, タツゾウ
サンノミヤ, カツタカ
玉木, 克佳
原田, 永勝
庄野, 正行
清水, 一郎
高山, 哲治
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In inflammatory and oxidative liver injury, virus proteins and reactive oxygen species are involved in the regulation of proinflammatory cytokine production by macrophages. This study investigated the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stress-stimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, macrophage inflammatory protein (MIP)-2, and macrophage chemotactic protein (MCP)-1 by peritoneal macrophages isolated from male and female mice. E2 inhibited the cytokine production of TNF-α, IL-1β, MIP-2, and MCP-1 by the unstimulated macrophages from males and females, which was then further stimulated by progesterone. The exposure to hydrogen peroxide in the macrophages from both sexes induced the production of cytokine. The hydrogen peroxide-stimulated cytokine production was suppressed by E2 and enhanced by progesterone. The sex hormone effects on the unstimulated and stimulated macrophages were blocked by their receptor antagonists and showed no significant difference between male and female subjects. These findings suggest that E2 may play a favorable role in the course of persistent liver injury, by inhibiting proinflammatory cytokine production, which, in addition, progesterone may counteract the favorable E2 effects through their receptors. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
estradiol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
progesterone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
macrophage |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ER |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
progesterone receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
proinflammatory cytokine |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 55,
号 1-2,
p. 133-141,
発行日 2008-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
|
|
識別子 |
210397 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_55_1-2_133.pdf (846 KB)
