| Item type |
文献 / Documents(1) |
| 公開日 |
2017-11-20 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.2152/jmi.55.183 |
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関連名称 |
10.2152/jmi.55.183 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats |
| 著者 |
サトウ, カズサ
アライ, ヒデカズ
ミヤザワ, ユイ
フカヤ, マキコ
上番増, 喬
コガネイ, メグミ
ササキ, ハジメ
サトウ, タダトシ
山本, 浩範
竹谷, 豊
武田, 英二
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| 抄録 |
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内容記述 |
We showed previously that 8-wk consumption of a diet containing palatinose (P, a slowly-absorbed sucrose analogue) and oleic acid (O) ameliorates but a diet containing sucrose (S) and linoleic acid (L) aggravates metabolic abnormalities in Zucker fatty (fa/fa) rats. In this study, we aimed to identify early changes in metabolism in rats induced by certain combinations of carbohydrates and fatty acids. Specifically, male Zucker fatty rats were fed an isocaloric diet containing various combinations of carbohydrates (P S) and fatty acids (O L). After 4 wk, no significant differences in bodyweight, visceral fat mass, plasma parameters (glucose, insulin, lipids, and adipokines), hepatic adiposity and gene expression, and adipose inflammation were observed between dietary groups. In contrast, pancreatic islets of palatinose-fed (PO and PL) rats were smaller and less fibrotic than sucrose-fed (SO and SL) rats. The abnormal_-cell distribution and sporadic staining of active caspase-3 common to islets of linoleic-acid-fed rats were not observed in oleic-acid-fed (PO and SO) rats. Accordingly, progressive_-cell loss was seen in SL rats, but not in PO rats. These findings suggest that pancreatic islets may be initial sites that translate the effects of different combinations of dietary carbohydrates and fats into metabolic changes. |
| キーワード |
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|
主題 |
Zucker fatty (fa/fa) rats |
| キーワード |
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主題 |
isomaltulose (palatinose) |
| キーワード |
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主題 |
sucrose |
| キーワード |
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|
主題 |
oleic acid |
| キーワード |
|
|
主題 |
linoleic acid |
| キーワード |
|
|
主題 |
pancreatic islet |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 55,
号 3-4,
p. 183-195,
発行日 2008-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13431420 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| EID |
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|
識別子 |
190350 |
| 言語 |
|
|
言語 |
eng |
jmi_55_3-4_183.pdf (877 KB)
