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Growth ability in simian cells of monkey cell-tropic HIV-1 is greatly affected by downstream region of the vif gene
https://tokushima-u.repo.nii.ac.jp/records/2004062
https://tokushima-u.repo.nii.ac.jp/records/200406291732a24-583d-4dee-aded-630b18452c51
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_55_3-4_236.pdf (1.39 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2017-11-20 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Growth ability in simian cells of monkey cell-tropic HIV-1 is greatly affected by downstream region of the vif gene | |||||||||||||||||||||||
| 著者 |
ヤマシタ, トモキ
× ヤマシタ, トモキ
× 土肥, 直哉× 足立, 昭夫
WEKO
1594
× 野間口, 雅子
WEKO
246
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| 内容記述 | To obtain monkey-tropic (mt) HIV-1 derivatives with distinct biological characteristics and to improve the viral growth property, we have generated several variants from a prototype mt HIV-1 designated NL-DT5R (X4-tropic). The prototype HIV-1 contains a portion of gag and entire vif genes from SIVmac in its genome. The two derivatives carrying 3’ half-genomic region of the SF162 (R5-tropic) or 89.6 (dual-tropic) isolate displayed very retarded or no viral growth, respectively, in a simian cell line HSC-F. In contrast, the three clones containing a part of env gene (encoding the V1-V4 region) from SF162, YU-2 (R5-tropic) or 89.6 showed different growth kinetics in HSC-F cells, although they grew somewhat more poorly than the NL-DT5R. Comparison of various viral proteins potentially involved in the different biological properties has revealed that, while amino acid sequences of Tat, Rev, Vpr, Vpu and Nef are quite conserved among the clones, those in the surface (SU) region of Env are relatively heterologous. Our data described here have shown that the 3’ half of viral genome other than gag and vif genes greatly affects the growth property of mt HIV-1 in simian cells. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | HIV-1 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Gag | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Env | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Vif | |||||||||||||||||||||||
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| 主題 | monkey cell tropism | |||||||||||||||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 55, 号 3-4, p. 236-240, 発行日 2008-08 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 224135 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
