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Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance
https://tokushima-u.repo.nii.ac.jp/records/2004167
https://tokushima-u.repo.nii.ac.jp/records/2004167ae92aad4-450b-4835-93e8-dbb8a11d4b62
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fimmu_8_403.pdf (1.94 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2017-12-28 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.3389/fimmu.2017.00403 | |||||||||||||||||
| 関連名称 | 10.3389/fimmu.2017.00403 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance | |||||||||||||||||
| 著者 |
山田, 安希子
× 山田, 安希子× 新垣, 理恵子× 齋藤, 雅子× 工藤, 保誠
WEKO
572
× 石丸, 直澄
WEKO
1721
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| 抄録 | ||||||||||||||||||
| 内容記述 | Fas-mediated apoptosis contributes to physiological and pathological cellular processes, such as differentiation and survival. In particular, the roles of Fas in immune cells are complex and critical for the maintenance of immune tolerance. The precise pathways and unique functions associated with Fas/FasL-mediated signaling in the immune system are known. The dual character of Fas/FasL-mediated immune regulation that induces beneficial or harmful effects is associated with the onset or development of immune disorders. Studies on mutations in genes encoding Fas and FasL gene of humans and mice contributed to our understanding of the pathogenesis of autoimmune diseases. Here, we review the opposing functions of Fas/FasL-mediated signaling, bilateral effects of Fas/FasL on in immune cells, and complex pathogenesis of autoimmunity mediated by Fas/FasL. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Fas | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | FasL | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | T cell | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | B cell | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | apoptosis | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | activation-induced cell death | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | autoimmunity | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | immune tolerance | |||||||||||||||||
| 書誌情報 |
en : Frontiers in Immunology 巻 8, p. Article403, 発行日 2017-04-05 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 16643224 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Frontiers Media SA | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | Copyright © 2017 Yamada, Arakaki, Saito, Kudo and Ishimaru. This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 326914 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
