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The non-canonical role of Aurora-A in DNA replication
https://tokushima-u.repo.nii.ac.jp/records/2004172
https://tokushima-u.repo.nii.ac.jp/records/20041723473db8a-fbdc-4a10-90bb-44f76090ad23
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fonc_5_187.pdf (390 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2017-12-28 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3389/fonc.2015.00187 | |||||||||||||||||||||||
| 関連名称 | 10.3389/fonc.2015.00187 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | The non-canonical role of Aurora-A in DNA replication | |||||||||||||||||||||||
| 著者 |
常松, 貴明
× 常松, 貴明
WEKO
813
× 新垣, 理恵子× 山田, 安希子× 石丸, 直澄
WEKO
1721
× 工藤, 保誠
WEKO
572
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Aurora-A is a well-known mitotic kinase that regulates mitotic entry, spindle formation, and chromosome maturation as a canonical role. During mitosis, Aurora-A protein is stabilized by its phosphorylation at Ser51 via blocking anaphase-promoting complex/cyclosome-mediated proteolysis. Importantly, overexpression and/or hyperactivation of Aurora-A is involved in tumorigenesis via aneuploidy and genomic instability. Recently, the novel function of Aurora-A for DNA replication has been revealed. In mammalian cells, DNA replication is strictly regulated for preventing over-replication. Pre-replication complex (pre-RC) formation is required for DNA replication as an initiation step occurring at the origin of replication. The timing of pre-RC formation depends on the protein level of geminin, which is controlled by the ubiquitin–proteasome pathway. Aurora-A phosphorylates geminin to prevent its ubiquitin-mediated proteolysis at the mitotic phase to ensure proper pre-RC formation and ensuing DNA replication. In this review, we introduce the novel non-canonical role of Aurora-A in DNA replication. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Aurora-A | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | geminin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | DNA replication | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | pre-RC | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | ubiquitin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | proteasome | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | degradation | |||||||||||||||||||||||
| 書誌情報 |
en : Frontiers in Oncology 巻 5, p. 187, 発行日 2015-08-25 |
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| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 2234943X | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Frontiers Media SA | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | Copyright © 2015 Tsunematsu, Arakaki, Yamada, Ishimaru and Kudo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publica- tion in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 315180 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
