| Item type |
文献 / Documents(1) |
| 公開日 |
2017-12-28 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.18632/oncotarget.20926 |
|
|
言語 |
ja |
|
|
関連名称 |
10.18632/oncotarget.20926 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression |
|
言語 |
en |
| 著者 |
フジタ, ユウジ
増田, 清士
ハマダ, ジュンイチ
ショウダ, カツトシ
成戸, 卓也
ハマダ, サトシ
宮上, 侑子
コウモト, トモヒロ
ワタナベ, ミキ
タカハシ, リズ
丹下, 正一朗
齋藤, 雅子
工藤, 保誠
フジワラ, ヒトシ
イチカワ, ダイスケ
丹黒, 章
オオツジ, エイゴ
井本, 逸勢
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein, which is involved in several post-transcriptional aspects of RNA metabolism, including microRNA (miRNA) biogenesis. It affects distinct cell functions in different tissues and can have an impact on various pathological conditions. In the present study, we investigated the oncogenic functions of KHSRP and their underlying mechanisms in the pathogenesis of esophageal squamous cell carcinoma (ESCC). KHSRP expression levels were elevated in ESCC tumors when compared with those in non-tumorous tissues by immunohistochemistry, and cytoplasmic KHSRP overexpression was found to be an independent prognosticator for worse overall survival in a cohort of 104 patients with ESCC. KHSRP knockdown inhibited growth, migration, and invasion of ESCC cells. KHSRP knockdown also inhibited the maturation of cancer-associated miRNAs, such as miR-21, miR-130b, and miR-301, and induced the expression of their target mRNAs, such as BMP6, PDCD4, and TIMP3, resulting in the inhibition of epithelial-to-mesenchymal transition. Our findings uncover a novel oncogenic function of KHSRP in esophageal tumorigenesis and implicate its use as a marker for prognostic evaluation and as a putative therapeutic target in ESCC. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
KHSRP |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oncogene |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
RNA-binding protein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microRNA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
esophageal squamous cell carcinoma |
| 書誌情報 |
en : Oncotarget
巻 8,
号 60,
p. 101130-101145,
発行日 2017-09-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19492553 |
| 出版者 |
|
|
出版者 |
Impact Journals |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Copyright: Fujita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
335884 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
onc_8_60_101130.pdf (4.81 MB)
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