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Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production
https://tokushima-u.repo.nii.ac.jp/records/2004367
https://tokushima-u.repo.nii.ac.jp/records/2004367f4d2e748-147d-4d15-a964-abfedd92e9fb
| 名前 / ファイル | ライセンス | アクション |
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jmi_63_3-4_187.pdf (537 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2018-04-23 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.63.187 | |||||||||||||||||||||||
| 関連名称 | 10.2152/jmi.63.187 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production | |||||||||||||||||||||||
| 著者 |
ヨシダ, シンヤ
× ヨシダ, シンヤ
× 安友, 康二
WEKO
1521
× ワタナベ, トシユキ
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| 内容記述 | Atopic dermatitis (AD) is caused by both dysregulated immune responses and an impaired skin barrier. Although leukotriene B4 (LTB4) is involved in tissue inflammation that occurs in several disorders, including AD, therapeutic strategies based on LTB4 inhibition have not been explored. Here we demonstrate that progression of an AD-like skin disease in NC/Nga mice is inhibited when docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) is administered together with FK506. Treatment with DHA/EPA and FK506 decreases the clinical score of dermatitis in NC/Nga mice and lowers local LTB4 concentrations. The treatment also suppressed the infiltration of T cells, B cells, eosinophils and neutrophils, and promoted reduced serum IgE levels. Secretion of IL-13 and IL-17A in CD4+ T cells was lower in DHA/EPA- and FK506-treated mice than in mice treated with FK506 alone. The inhibition of disease progression induced by DHA/EPA was reversed by local injection of LTB4, suggesting that the therapeutic effect of DHA/EPA is LTB4-dependent. Our results demonstrate that treatment of AD with DHA/EPA is effective for allergic skin inflammation and acts by suppressing LTB4 production. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | docosahexaenoic acid | |||||||||||||||||||||||
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| 主題 | eicosapentaenoic acid | |||||||||||||||||||||||
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| 主題 | atopic dermatitis | |||||||||||||||||||||||
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| 主題 | leukotriene B4 | |||||||||||||||||||||||
| 書誌情報 |
en : The Journal of Medical Investigation 巻 63, 号 3-4, p. 187-191, 発行日 2016-08 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13496867 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA12022913 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Faculty of Medicine Tokushima University | |||||||||||||||||||||||
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| 識別子 | 320769 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
