| Item type |
文献 / Documents(1) |
| 公開日 |
2018-04-23 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.63.236 |
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|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.63.236 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Assay of serum E2 concentration inpostmenopausal breast cancer patients using a high-sensitivity RIA method is generally useful |
|
言語 |
en |
| 著者 |
モリモト, マサミ
タカハシ, マサコ
本田, 純子
吉田, 卓弘
吉田, 光輝
鳥羽, 博明
井本, 逸勢
丹黒, 章
ササ, ミツノリ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background : Serum E2 must be monitored for aromatase inhibitor (AI) therapy, but conventional assays lack sensitivity. Subjects/Methods : Forty amenorrheic breast cancer patients scheduled for AI treatment but requiring hormonological confirmation of their menopausal status were studied. Serum E2 data generated by high-sensitivity RIA and by LC-MS/MS were analyzed for correlation. Results : RIA gave a higher E2 value than LC-MS/MS in 62% of cases, but there was a significant positive correlation. Patients whose E2 levels by RIA were≥2.5 pg/mL higher than those by LC-MS/MS (RIA-H group) and all other patients (RIA-N group) were compared. Both groups showed strong correlations between the two assay methods. With both methods patients with a high BMI had significantly elevated E2. Multiple regression analysis used age, age at menarche, number of births and BMI as explanatory variables. Significant variables were the BMI with LC-MS/MS, and both BMI and age with RIA. The RIA-H and RIA-N groups showed no difference in regard to the BMI, whereas the age was significantly lower in the RIA-H group. Summary : Serum E2 levels determined for postmenopausal women by RIA and LC-MS/MS generally correlated well. High-sensitivity RIA is a potentially useful clinical assay, but it overestimated serum E2 in some women. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Breast cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
post-menopausal women |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serum E2 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
high-sensitivity RIA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LC-MS/MS |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 63,
号 3-4,
p. 236-240,
発行日 2016-08
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| EID |
|
|
識別子 |
323071 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_63_3-4_236.pdf (322 KB)
