| Item type |
文献 / Documents(1) |
| 公開日 |
2018-05-10 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.62.29 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.62.29 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Neuroimaging in autism spectrum disorders : 1H-MRS and NIRS study |
|
言語 |
en |
| 著者 |
森, 健治
東田, 好広
伊藤, 弘道
森, 達夫
森, 恵子
郷司, 彩
橋本, 浩子
(出口)谷, 洋江
ミヤザキ, マサヒト
原田, 雅史
香美, 祥二
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Using proton magnetic resonance spectroscopy (1H-MRS), we measured chemical metabolites in the left amygdala and the bilateral orbito-frontal cortex (OFC) in children with autism spectrum disorders (ASD). The concentrations of N-acetylaspartate (NAA) in these regions of ASD were significantly decreased compared to those in the control group. In the autistic patients, the NAA concentrations in these regions correlated with their social quotient. These findings suggest the presence of neuronal dysfunction in the amygdala and OFC in ASD. Dysfunction in the amygdala and OFCmay contribute to the pathogenesis of ASD.We performed a near-infrared spectroscopy (NIRS) study to evaluate the mirror neuron system in children with ASD. The concentrations of oxygenated hemoglobin (oxy-Hb) were measured with frontal probes using a 34-channel NIRS machine while the subjects imitated emotional facial expressions. The increments in the concentration of oxy-Hb in the pars opercularis of the inferior frontal gyrus in autistic subjects were significantly lower than those in the controls. However, the concentrations of oxy-Hb in this area were significantly elevated in autistic subjects after they were trained to imitate emotional facial expressions. The results suggest that mirror neurons could be activated by repeated imitation in children with ASD. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
autism |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
proton magnetic resonance spectroscopy (1H-MRS) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
amygdala |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
near-infrared spectroscopy (NIRS) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mirror neuron |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 62,
号 1-2,
p. 29-36,
発行日 2015-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| EID |
|
|
識別子 |
303126 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_62_1-2_29.pdf (909 KB)
