| Item type |
文献 / Documents(1) |
| 公開日 |
2018-05-21 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.2152/jmi.62.199 |
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関連名称 |
10.2152/jmi.62.199 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Intracerebroventricular injection of adiponectin regulates locomotor activity in rats |
| 著者 |
ミヤタケ, ユミコ
志内, 哲也
ウエタ, トモヨ
タニグチ, ヤスコ
フタミ, アカリ
サトウ, フキコ
キタムラ, タダヒロ
堤, 理恵
原田, 永勝
中屋, 豊
阪上, 浩
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| 抄録 |
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内容記述 |
Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays : home cage and wheel running activity. SPORTS rats were established from an original line from Wister strain that had shown high level of wheel running activity in our laboratory. Injection of adiponectin into the lateral ventricle of Wister rats and SPORTS rats decreased home cage activity, but no change was observed in the food intake and oxygen consumption. This result indicates the possibility that adiponectin can reduce non-exercise activity thermogenesis (NEAT) and physical activity via the central nervous system. In contrast, injection of adiponectin did not change wheel running activity in SPORTS rats. We produced hypothalamus-destructed model rat using monosodium glutamate (MSG) to elucidate the regulation site of adiponectin. Injection of adiponectin into MSG-treated SPORTS rats did not change amount of home cage activity and food intake, suggesting that adiponectin action on home cage activity was in the hypothalamic area. These results suggest that adiponectin regulates locomotion activity through mediobasal hypothalamus. |
| キーワード |
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|
主題 |
Adiponectin |
| キーワード |
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主題 |
spontaneous activity |
| キーワード |
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主題 |
brain |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 62,
号 3-4,
p. 199-203,
発行日 2015-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
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|
出版者 |
Faculty of Medicine Tokushima University |
| EID |
|
|
識別子 |
315288 |
| 言語 |
|
|
言語 |
eng |
jmi_62_3-4_199.pdf (530 KB)
