| Item type |
文献 / Documents(1) |
| 公開日 |
2018-05-22 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.2152/jmi.56.120 |
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関連名称 |
10.2152/jmi.56.120 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
L-DOPA inhibits nitric oxide-dependent vasorelaxation via production of reactive oxygen species in rat aorta |
| 著者 |
Yin, Hua
原田, 永勝
馬渡, 一諭
(安井)山田, 苑子
瀬川, 博子
髙橋, 章
大下, 修造
中屋, 豊
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| 抄録 |
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内容記述 |
Objectives : To clarify the underlying mechanisms of L-DOPA induced vasoconstriction in rat aorta. Methods : The effect of L-DOPA on phenylephrine-induced contractile force of blood vessels was examined in vitro using rat aortic ring preparations by isometric tension experiment. Involvement of nitric oxide (NO) in the effect of L-DOPA on vascular smooth muscle was studied by using Nω-Nitro-L-arginine (L-NNA), Sodium nitroprusside (SNP) in endothelium-intact and endothelium-denuded aortic rings. Results : L-DOPA potentiated α-adrenergic receptor- and depolarization-induced vascular contraction and inhibited acetylcholine-induced vasorelaxation. This effect was diminished by pretreatment of the aortic rings with L-NNA, an inhibitor of NO synthesis, or by removing the endothelium from the ring preparations. In endothelium-denuded rings, L-DOPA inhibited exogenous NO-dependent but not cGMP-mediated vasorelaxation. Increases in cGMP levels in response to an NO donor were attenuated by L-DOPA in cultured rat aortic smooth muscle cells. L-DOPA could not contract rings (without endothelium) pretreated with 3-(5’-hydroxymethyl- 2’-furyl)-1-benzyl indazole (YC-1), an activator of guanylyl cyclase, but SOD (150 U/ml) pretreatment of rings with endothelium inhibited contraction by L-DOPA. Conclusions : These results suggest that L-DOPA inhibits nitric-dependent vasorelaxation on vascular smooth muscle cells via production of reactive oxygen species. |
| キーワード |
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主題 |
L-DOPA |
| キーワード |
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主題 |
aortic rings |
| キーワード |
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主題 |
nitric oxide |
| キーワード |
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|
主題 |
vasorelaxation |
| キーワード |
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|
主題 |
reactive oxygen species |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 56,
号 3-4,
p. 120-129,
発行日 2009-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13496867 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13431420 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
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|
出版者 |
Faculty of Medicine Tokushima University |
| EID |
|
|
識別子 |
195202 |
| 言語 |
|
|
言語 |
eng |
jmi_56_3-4_120.pdf (982 KB)
