WEKO3
アイテム
Salivary gland and autoimmunity
https://tokushima-u.repo.nii.ac.jp/records/2004513
https://tokushima-u.repo.nii.ac.jp/records/2004513a70121a3-7b70-4842-b099-ab4ea980a298
| 名前 / ファイル | ライセンス | アクション |
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jmi_56_suppl_185.pdf (462 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2018-06-01 | |||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.56.185 | |||||||||||||||||
| 関連名称 | 10.2152/jmi.56.185 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Salivary gland and autoimmunity | |||||||||||||||||
| 著者 |
林, 良夫
× 林, 良夫
WEKO
1659
× 新垣, 理恵子× 石丸, 直澄
WEKO
1721
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| 内容記述 | Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T cells to tissue-specific self antigen, and may drive the autoimmune phenomenon in the salivary glands. We found that retinoblastoma-associated protein RbAp48 overexpression induces p53-mediated apoptosis in the salivary glands caused by estrogen deficiency. We demonstrated that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjögren’s syndrome (SS). CD4+T cell-mediated autoimmune lesions in the salivary glands were aggravated with age, in association with autoantibody productions. We obtained evidences that salivary epithelial cells can produce interferon-γ(IFN-γ) besides interleukin (IL)-18, which activates interferon regulatory factor-1 (IRF-1), and class II transactivator (CIITA). Indeed, the autoimmune lesions into Rag2-/- mice were induced by the adoptive transfer of lymph node cells from RbAp48-Tg mice. These results indicate a novel immunocompetent role of epithelial cells that can produce IFN-γ, resulting in loss of local tolerance prior to developing gender-based autoimmunity. The studies reviewed the molecular mechanisms on the development of salivary gland autoimmunity, and gender-related differences in SS. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Salivary gland | |||||||||||||||||
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| 主題 | autoimmunity | |||||||||||||||||
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| 主題 | RbAp48 | |||||||||||||||||
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| 主題 | Sjögren’s syndrome | |||||||||||||||||
| 書誌情報 |
en : The Journal of Medical Investigation 巻 56, 号 Supplement, p. 185-191, 発行日 2009-12 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 13496867 | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12022913 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Faculty of Medicine Tokushima University | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 206820 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
