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Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues
https://tokushima-u.repo.nii.ac.jp/records/2004637
https://tokushima-u.repo.nii.ac.jp/records/2004637d4eadc23-0858-4178-9426-9210f892a472
| 名前 / ファイル | ライセンス | アクション |
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jmi_56_suppl_343.pdf (64.4 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2018-06-22 | |||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.56.343 | |||||||||||||||||||||||||
| 関連名称 | 10.2152/jmi.56.343 | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues | |||||||||||||||||||||||||
| 著者 |
Wang, Chun
× Wang, Chun
× Chen, Gang
× Jiang, Junkang
× Qiu, Lianglin
× 細井, 和雄
WEKO
169
× 姚, 陳娟
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226
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| 内容記述 | Aquaglyceroporins (AQGPs) are members of aquaporin (AQP) family and belong to a subgroup of this water channel family ; they are transmembrane proteins that transport water as well as glycerol and other solutes of small molecules. Recent studies have also identified that AQGPs are important transporters of trivalent metalloid in some mammalian cells. However, the uptake routes of arsenite in mammals are still less defined. In this study, to understand the routes of arsenite intake in mammals, mice were treated with Hg(II), glycerol, and As(III) and uptake of As(III) into the gastrointestinal tissues was measured. The level of inorganic arsenic (iAs) in gastrointestinal tissues after As(III) stimulation was much higher than Hg(II) +As(III) or glycerol+As(III) group. RT-PCR results showed that AQGPs were extensively expressed in gastrointestinal tissues of mice. We also treated Caco-2 cells with Hg(II) and As(III) ; the level of iAs in a group treated with Hg(II)+As(III) decreased compared with As(III)-treated group. Our results suggested that AQGPs could be important transporters in arsenite uptake into gastrointestinal tissues of mice, but more data are need to prove if AQGPs is the only pathway involved in As transport in mammals or just one of them. | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | aquaglyceroporins (AQGPs) | |||||||||||||||||||||||||
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| 主題 | arsenite | |||||||||||||||||||||||||
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| 主題 | gastrointestinal tissues | |||||||||||||||||||||||||
| 書誌情報 |
en : The Journal of Medical Investigation 巻 56, 号 Supplement, p. 343-346, 発行日 2009-12 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 13496867 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA12022913 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | Faculty of Medicine Tokushima University | |||||||||||||||||||||||||
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| 識別子 | 213994 | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
