| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-03 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.2152/jmi.56.375 |
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言語 |
ja |
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関連名称 |
10.2152/jmi.56.375 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts |
|
言語 |
en |
| 著者 |
オノ, ケンタロウ
イナガキ, トモヒロ
イイダ, タイチ
ホソカワ, リュウジ
イネナガ, キヨトシ
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that induced by cevimeline in rats (2, 3). Therefore, in the present study, sialogogue-induced intracellular Ca2+ mobilization was investigated in isolated parotid gland cells in vitro. Pilocarpine and cevimeline increased the intracellular Ca2+ concentration of parotid gland acinar and duct cells over 1 μM in a dose-dependent manner. Pilocarpine-induced responses were higher than cevimeline-induced responses. Ca2+ responses to both agents were completely blocked by 1 μM 4-DAMP, an M3 muscarinic receptor antagonist. In the absence of extracellular Ca2+, both sialogogues induced transient Ca2+ increase in parotid gland acinar cells. These results suggest that the sialogogues stimulate some common routes via the Ca2+ signaling in parotid gland acinar cells. We also report a significant difference of Ca2+ responses in concentration between pilocarpine and cevimeline in parotid gland acinar cells. The different Ca2+ responses between the sialogogues would explain the different saliva volumes from the parotid gland between them that we have observed in previous in vivo studies (2, 3). |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pilocarpine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cevimeline |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
parotid cells |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 56,
号 Supplement,
p. 375-375,
発行日 2009-12
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
jmi_56_suppl_375.pdf (39 KB)
