WEKO3
-
RootNode
アイテム
Differences of therapeutic effects on regional bone mineral density and markers of bone mineral metabolism between alendronate and alfacalcidol in Japanese osteoporotic women
https://tokushima-u.repo.nii.ac.jp/records/2004671
https://tokushima-u.repo.nii.ac.jp/records/20046718ada1ba1-dad3-4726-bc6b-f9a90948587a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_54_1-2_35.pdf (484 KB)
|
|
| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2018-05-28 | |||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.54.35 | |||||||||||||||||||||||||
| 関連名称 | 10.2152/jmi.54.35 | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Differences of therapeutic effects on regional bone mineral density and markers of bone mineral metabolism between alendronate and alfacalcidol in Japanese osteoporotic women | |||||||||||||||||||||||||
| 著者 |
髙田, 信二郎
× 髙田, 信二郎
× Abbaspour, Aziz
× 米津, 浩
× 安井, 夏生
WEKO
1520
|
|||||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | We studied the differences of therapeutic effects on regional bone mineral density (BMD) and markers of bone mineral metabolism between alendronate and alfacalcidol in Japanese osteoporotic women. Ninety-two Japanese women suffering from primary osteoporosis without osteoporotic fractures, aged 55 to 81 years, were divided into two groups : women treated orally with alendronate for one-year (5mg/day)(alendronate group, n=35) and women treated orally with alfacalcidol for one year (0.5μg/ day) (alfacalcidol group, n=57). The mean BMD of the 2nd to 4th lumbar vertebrae (L2-4 BMD) and regional BMD were measured using dual energy X-ray absorptiometry. In the alendronate group, the percentage changes of L2-4BMD, lumbar spine BMD, thoracic spine BMD, pelvis BMD in the alendronate group were 106.3±4.6%, 104.2±6.6%, 107.1± 10.4%, 107.1±10.5%, respectively. The percentage changes of L2-4BMD and regional BMD except for head BMD in the alendronate group were significantly greater than those in the alfacalcidol group. In the alfacalcidol group, L2-4BMD, thoracic spine BMD and lumbar spine BMD were maintained at respective pretreatment levels, whereas other regional BMD were decreased. Both serum bone-specific alkaline phosphatase and urinary type I collagen cross-linked N-telopeptide of the alendronate group were decreased, whereas these markers of bone mineral metabolism of alfacalcidol group were increased compared with the respective pre-treatment levels. The results suggest that one-year treatment with alendronate increased L2-4BMD, lumbar spine BMD, thoracic spine BMD and pelvis BMD, and that markers of both bone formation and bone resorption were decreased following one-year treatment with alendronate. | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | alendronate | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | alfacalcidol | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | bone mineral density | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | bone mineral content | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | markers of bone mineral metabolism | |||||||||||||||||||||||||
| 書誌情報 |
en : The Journal of Medical Investigation 巻 54, 号 1-2, p. 35-40, 発行日 2007-02 |
|||||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 13496867 | |||||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA12022913 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | Faculty of Medicine Tokushima University | |||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||
| 識別子 | 213869 | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
