| Item type |
文献 / Documents(1) |
| 公開日 |
2018-05-28 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.2152/jmi.54.35 |
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|
言語 |
ja |
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|
関連名称 |
10.2152/jmi.54.35 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Differences of therapeutic effects on regional bone mineral density and markers of bone mineral metabolism between alendronate and alfacalcidol in Japanese osteoporotic women |
|
言語 |
en |
| 著者 |
髙田, 信二郎
Abbaspour, Aziz
米津, 浩
安井, 夏生
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| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
We studied the differences of therapeutic effects on regional bone mineral density (BMD) and markers of bone mineral metabolism between alendronate and alfacalcidol in Japanese osteoporotic women. Ninety-two Japanese women suffering from primary osteoporosis without osteoporotic fractures, aged 55 to 81 years, were divided into two groups : women treated orally with alendronate for one-year (5mg/day)(alendronate group, n=35) and women treated orally with alfacalcidol for one year (0.5μg/ day) (alfacalcidol group, n=57). The mean BMD of the 2nd to 4th lumbar vertebrae (L2-4 BMD) and regional BMD were measured using dual energy X-ray absorptiometry. In the alendronate group, the percentage changes of L2-4BMD, lumbar spine BMD, thoracic spine BMD, pelvis BMD in the alendronate group were 106.3±4.6%, 104.2±6.6%, 107.1± 10.4%, 107.1±10.5%, respectively. The percentage changes of L2-4BMD and regional BMD except for head BMD in the alendronate group were significantly greater than those in the alfacalcidol group. In the alfacalcidol group, L2-4BMD, thoracic spine BMD and lumbar spine BMD were maintained at respective pretreatment levels, whereas other regional BMD were decreased. Both serum bone-specific alkaline phosphatase and urinary type I collagen cross-linked N-telopeptide of the alendronate group were decreased, whereas these markers of bone mineral metabolism of alfacalcidol group were increased compared with the respective pre-treatment levels. The results suggest that one-year treatment with alendronate increased L2-4BMD, lumbar spine BMD, thoracic spine BMD and pelvis BMD, and that markers of both bone formation and bone resorption were decreased following one-year treatment with alendronate. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alendronate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alfacalcidol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone mineral density |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone mineral content |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
markers of bone mineral metabolism |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 54,
号 1-2,
p. 35-40,
発行日 2007-02
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| EID |
|
|
識別子 |
213869 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_54_1-2_35.pdf (484 KB)
