| Item type |
文献 / Documents(1) |
| 公開日 |
2018-06-06 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.54.235 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.54.235 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The nucleoside and nucleotide mixture (OG-VI) rescues intestinal-like epithelial cells from the cytotoxicity of chemotherapeutic agents |
|
言語 |
en |
| 著者 |
オノ, カオリ
馬渡, 一諭
原田, 永勝
髙橋, 章
酒井, 徹
オゴシ, ショウヘイ
中屋, 豊
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Immune cells and cells undergoing rapid turn-over can obtain exogenous nucleotides via salvage synthesis. We evaluated whether or not the balanced nucleoside and nucleotide mixture OG-VI, could rescue intestinal epithelial-like Caco-2 cells from the cytotoxic effects of several chemotherapeutic agents, in the presence and absence of glutamine (Gln). Cells were exposed to 5-fluorouracil (5FU), methotrexate (MTX) or 6-mercaptopurine (6MP), after which proliferation and cell cycle analyses were performed. Following exposure to the chemotherapeutic agents, we observed that cells treated with OG-VI proliferated well, whereas those without the supplement did not proliferate. Furthermore, following treatment with either 5FU or MTX, we observed that the number of cells in the G0/G1 phase decreased and those in the S phases increased. However, these cell cycle alterations were prevented by the addition of OG-VI. With the exception of 6MP-treated cells, we did not observe any effects on proliferation or cell cycle regulation that could be ascribed to the presence of Gln. Thus, we have demonstrated that OG-VI rescues cells from the cytotoxic effects of several chemotherapeutic agents. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
exogenous nucleotides |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
5-fluorouracil, glutamine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
OG-VI |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
methotrexate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
6-mercaptopurine |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 54,
号 3-4,
p. 235-242,
発行日 2007-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
|
|
出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| EID |
|
|
識別子 |
162985 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_54_3-4_235.pdf (670 KB)
