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Spatial learning and expression of neural cell adhesion molecule L1 in rats X-irradiated prenatally
https://tokushima-u.repo.nii.ac.jp/records/2004715
https://tokushima-u.repo.nii.ac.jp/records/20047154ee3e9f9-f5e9-48cc-9cbb-ac3a52c46e5b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jmi_54_3-4_322.pdf (684 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||
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| 公開日 | 2018-06-06 | |||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2152/jmi.54.322 | |||||||||||||||||||||||||
| 関連名称 | 10.2152/jmi.54.322 | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Spatial learning and expression of neural cell adhesion molecule L1 in rats X-irradiated prenatally | |||||||||||||||||||||||||
| 著者 |
Zhang, Rui
× Zhang, Rui
× Sun, Xue-Zhi
× Cui, Chun
× 坂田, ひろみ× サワダ, カズヒコ
× Ye, Changli
× 福井, 義浩
WEKO
1537
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| 内容記述 | The present study was designed to present evidence to clarify the relationships between learning ability, neuronal cell adhesion molecule L1 expression and hippocampal structural changes in the rat model received X-irradiation at an embryonic stage (E15). Water maze task indicated that all of the irradiated rats failed to learn the task in the whole training procedure. Their latency to the platform and swimming distance were significant differences from those sham-treated controls. Histological studies showed that the hippocampal ectopias induced by X-rays in the CA1 were involved in the spatial learning impairment, in which they hampered normal processes in learning development and transmission of information. Number, size and positions of the ectopias in the dorsal parts of the hippocampus were confirmed to be related to degrees of spatial learning impairment. On the other hand, L1 expression in the hippocampus was examined with Western blot analysis. The results indicated a lower content of L1 in the irradiated rats. A decrease in L1 might be one of reasons to cause disorganization of the septohippocampal pathways. These findings suggest some mechanisms of spatial learning impairment can be attributed to the formation of the hippocampal ectopias and redaction of L1 following prenatal exposure to X-irradiation. | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | hippocampus | |||||||||||||||||||||||||
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| 主題 | X-irradiation | |||||||||||||||||||||||||
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| 主題 | L1 | |||||||||||||||||||||||||
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| 主題 | learning | |||||||||||||||||||||||||
| 書誌情報 |
en : The Journal of Medical Investigation 巻 54, 号 3-4, p. 322-330, 発行日 2007-08 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 13496867 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||
| 収録物識別子 | 13431420 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA11166929 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA12022913 | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | Faculty of Medicine Tokushima University | |||||||||||||||||||||||||
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| 識別子 | 191735 | |||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||
