| Item type |
文献 / Documents(1) |
| 公開日 |
2018-06-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.2152/jmi.54.359 |
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言語 |
ja |
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|
関連名称 |
10.2152/jmi.54.359 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Advantage of a low glycemic index and low phosphate diet on diabetic nephropathy and aging-related diseases |
|
言語 |
en |
| 著者 |
竹谷, 豊
首藤, 恵泉
新井, 英一
ニシダ, ユカ
タナカ, リエコ
上番増, 喬
山本, 浩範
(山中)奥村, 仙示
武田, 英二
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD) in Japan and other Westernized countries. Over 50% of the ESRD patients die from cardiovascular events. Cardiovascular disease (CVD) in ESRD patients with diabetes mellitus (DM) are implicated in the endothelial dysfunction caused by hyperglycemia, hyperlipidemia, and hypertension, and in the vascular calcification of intimal and medial arterial blood vessels caused by hyperphosphatemia. Therefore, dietary control of hyperglycemia and hyperphosphatemia should play an important role in the management of ESRD patients with DM. Furthermore, recent findings suggest that high concentrations of serum phosphate, even if within the normal range, may be a risk factor for CVD and mortality. An in vivo study using klotho knockout mice and fibroblast growth factor 23 (FGF-23) knockout mice has revealed that correction of hyperphosphatemia and hypervitaminosis D could ameliorate the premature aging-like phenotype. A low glycemic index and low phosphate diet may provide an advantage in the prevention of aging-related diseases in healthy individuals as well as in those with chronic kidney disease. |
|
言語 |
en |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 54,
号 3-4,
p. 359-365,
発行日 2007-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13496867 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12022913 |
| 出版者 |
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出版者 |
Faculty of Medicine Tokushima University |
|
言語 |
en |
| EID |
|
|
識別子 |
190360 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_54_3-4_359.pdf (516 KB)
