| Item type |
文献 / Documents(1) |
| 公開日 |
2018-06-14 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
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資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.4236/abc.2018.81001 |
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関連名称 |
10.4236/abc.2018.81001 |
| 出版タイプ |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
Distinct Gene Expression Profile Distinguishes Increased Metabolic Activity in Spontaneously Hyperactive Rats While Sedentary from That Induced by Exercise |
| タイトル別表記 |
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その他のタイトル |
自発的高運動ラットの安静時遺伝子発現パターンと野生型ラット運動時遺伝子発現パターンの違い |
| 著者 |
阿部, 愛波
マツオ, ユキ
ハラダ スケノ, アキコ
内田, 貴之
キタハタ, カナコ
トミダ, チサト
平坂, 勝也
(手嶋)近藤, 茂忠
原田, 永勝
中屋, 豊
阪上, 浩
中尾, 玲子
二川, 健
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| 抄録 |
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内容記述 |
The Spontaneously-Running Tokushima Shikoku (SPORTS) strain is an original line derived from Wistar rats, which spontaneously runs >6 km/day on wheels, and has better glucose tolerance and less fat than Wistar rats. However, the molecular mechanism that contributes to the increased metabolic activity in SPORTS rats is unknown. The present study aimed to characterize the gene expression profiles of skeletal muscles in SPORTS rats housed under sedentary (SED) conditions. We found that the expression levels of genes encoding mitochondrial respiratory chain enzymes such as ATP synthase 6 (mt-Atp6) and cytochrome c oxidase subunit 6c (Cox 6c), were higher in the soleus (SOL) muscles of SED SPORTS than in SED Wistar rats. The ratio of type IIa myofibers was higher and glucose tolerance was better in SED SPORTS than in Wistar rats that were sedentary and trained daily on treadmills, respectively. We then investigated candidate genes that might contribute to the better glucose tolerance of SED SPORTS rats using DNA microarray analysis. Among 116 upregulated genes in the SOL muscles of SED SPORTS rats, only 19 were also increased in trained Wistar rats. We focused on v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Erbb3), which was associated with glucose transport in myocytes, and found higher expression levels in the SOL muscles of SED SPORTS than in SED Wistar rats. The SOL muscles of SED SPORTS rats also contained more activity of β-hydroxy-acylCoA dehydrogenase, a key enzyme of β-oxidation, indicating enhanced lipid oxidation. These findings suggest that increased metabolic activity in skeletal muscle (especially the SOL muscle) of SPORTS rats is congenital and that gene expression profiles of SPORTS rats and Trained Wistar rats are different. |
| キーワード |
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主題 |
mitochondria |
| キーワード |
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主題 |
myofiber type |
| キーワード |
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主題 |
microarray |
| キーワード |
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主題 |
metabolism |
| 書誌情報 |
en : Advances in Biological Chemistry
巻 8,
号 1,
p. 1-14,
発行日 2018-02-05
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
21622191 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21622183 |
| 出版者 |
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出版者 |
Scientific Research Publishing |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Manami Abeの学位論文として提出され, 学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻） |
| 権利情報 |
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|
権利情報 |
© 2018 by authors and Scientific Research Publishing Inc.This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). |
| EID |
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識別子 |
337952 |
| 言語 |
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言語 |
eng |
| 報告番号 |
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学位授与番号 |
甲第3145号 |
| 学位記番号 |
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値 |
甲栄第254号 |
| 学位授与年月日 |
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学位授与年月日 |
2018-03-15 |
| 学位名 |
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学位名 |
博士（栄養学） |
| 学位授与機関 |
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|
学位授与機関名 |
徳島大学 |
k3145_abstract_review.pdf (356 KB)
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