| Item type |
文献 / Documents(1) |
| 公開日 |
2018-05-31 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1507/endocrj1954.35.97 |
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関連名称 |
10.1507/endocrj1954.35.97 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Ectopic Growth Hormone-Releasing Hormone (GHRH) Syndrome in a Case with Multiple Endocrine Neoplasia Type I |
| タイトル別表記 |
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その他のタイトル |
ECTOPIC GHRH SYNDROME IN MEN TYPE I |
| 著者 |
ヤマサキ, リュウイチ
サイトウ, ハルヒコ
佐野, 壽昭
カメヤマ, カズヒト
吉本, 勝彦
細井, 英司
マツムラ, ミツヒロ
ハラダ, クニヒコ
齋藤, 史郎
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| 抄録 |
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内容記述 |
A 36-yr-old man with multiple endocrine neoplasia (MEN) type I had an ectopic growth hormone-releasing hormone (GHRH) syndrome due to a GHRH-secreting pancreatic tumor. The immunoreactive (IR)-GHRH concentration in his plasma ranged from 161 to 400pg/ml (299±61pg/ml, mean±SD; normal, 10.4±4.1pg/ml), and a significant correlation was found between his plasma IR-GHRH and GH (r=0.622, p<0.02). After removal of the pancreatic tumor, the high plasma GH concentration returned to nearly the normal range (42.2±31.3 to 9.6±3.8ng/ml). These changes paralleled the normalization of his plasma IR-GHRH (16.1±3.8pg/ml) and some of his symptoms related to acromegaly improved. However, plasma GH (7.7±1.3ng/ml) and IGF-I (591± 22ng/ml) concentrations were high at 12 months after surgery, suggesting adenomatous changes in the pituitary somatotrophs.
Before surgery, exogenous GHRH induced a marked increase in plasma GH, and somatostatin and its agonist (SMS201-995) completely suppressed GH secretion, but not IR-GHRH release. No pulsatile secretion of either IR-GHRH or GH was observed during sleep. An apparent increase in the plasma GH concentration was observed in response to administration of TRH, glucose, arginine or insulin, while plasma IR-GHRH did not show any fluctuation. However, these responses of plasma GH were reduced or no longer observed one month and one year after surgery.
These results indicate that 1) a moderate increase in circulating GHRH due to ectopic secretion from a pancreatic tumor stimulated GH secretion resulting in acromegaly, and evoked GH responses to various provocative tests indistinguishable from those in patients with classical acromegaly, and 2) the ectopic secretion of GHRH may play an etiological role in the pituitary lesion of this patient with MEN type I. |
| 書誌情報 |
en : Endocrinologia Japonica
巻 35,
号 1,
p. 97-109,
発行日 1988-02
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
21856370 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00137219 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00635052 |
| 出版者 |
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出版者 |
The Japan Endocrine Society |
| EID |
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識別子 |
71291 |
| 言語 |
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言語 |
eng |
endocrj_35_1_97.pdf (8.55 MB)
