| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-13 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1002/open.201500086 |
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|
関連名称 |
10.1002/open.201500086 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System |
| 著者 |
ツダ, ユウスケ
重永, 章
ツジ, コウヘイ
傳田, 将也
サトウ, コウヘイ
キタカゼ, ケイスケ
ナカムラ, タカヒロ
猪熊, 翼
伊藤, 孝司
大髙, 章
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| 抄録 |
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内容記述 |
Peptide thioesters are very useful in protein chemistry, and chemistry- and biochemistry-based protocols are used for the preparation of thioesters. Among such protocols, only a few biochemistry-based approaches have been use for naturally occurring peptide sequences. The development of chemistry-based protocols applicable to natural sequences remains a challenge, and the development of such methods would be a major contribution to protein science. Here, we describe the preparation of peptide thioesters using innovative methodology that features nickel(II)-mediated alcoholysis of a naturally occurring peptide sequence, followed by O-N and N-S acyl transfers. This protocol involves sequential quadruple acyl transfer, termed SQAT. Notably, the SQAT system consists of sequential chemical reactions that allow naturally occurring peptide sequences to be converted to thioesters without requiring an artificial chemical unit. |
| キーワード |
|
|
主題 |
acyl transfer |
| キーワード |
|
|
主題 |
native chemical ligation |
| キーワード |
|
|
主題 |
nickel(II)-mediated alcoholysis |
| キーワード |
|
|
主題 |
peptide hydrazides |
| キーワード |
|
|
主題 |
peptide thioesters |
| 書誌情報 |
en : ChemistryOpen
巻 4,
号 4,
p. 448-452,
発行日 2015-04-28
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21911363 |
| 出版者 |
|
|
出版者 |
WILEY-VCH Verlag GmbH & Co. KGaA |
| 権利情報 |
|
|
権利情報 |
🄫2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| EID |
|
|
識別子 |
293018 |
| 言語 |
|
|
言語 |
eng |
chemop_4_4_448.pdf (561 KB)
