| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-03 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2018.01.175 |
|
|
関連名称 |
10.1016/j.bbrc.2018.01.175 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1 |
| 著者 |
オオウエ, ユナ
ムラカミ, サラ
イッシキ, キヌカ
辻, 明彦
湯浅, 恵造
|
| 抄録 |
|
|
内容記述 |
Death associated protein kinase (DAPK)-related apoptosis-inducing protein kinase (DRAK)-1 is a positive apoptosis regulator. However, the molecular mechanisms underlying the DRAK1-mediated apoptotic pathway remain unclear. In this study, we demonstrated the intracellular localization and binding partners of DRAK1. In human osteosarcoma cell line U2OS cells, DRAK1 was mainly localized in the nucleus and translocated outside the nucleus through Ser395 phosphorylation by protein kinase C. In the nucleus, DRAK1 associated with tumor suppressor p53 and positively regulated p53 transcriptional activity in response to DNA-damaging agent cisplatin. On the other hand, DRAK1 interacted with the mitochondrial inner-membrane protein, adenine nucleotide translocase (ANT)-2, an anti-apoptotic oncoprotein, outside the nucleus. These findings suggest that DRAK1 translocates in response to stimuli and induces apoptosis through its interaction with specific binding partners, p53 and/or ANT2. |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 496,
号 4,
p. 1222-1228,
発行日 2018-01-31
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006291X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11542044 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
337905 |
| 言語 |
|
|
言語 |
eng |
bbrc_496_4_1222.pdf (1.04 MB)
