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口腔Biofilm感染症における病原因子と全身に及ぼす影響
https://tokushima-u.repo.nii.ac.jp/records/2005096
https://tokushima-u.repo.nii.ac.jp/records/2005096aee5d540-d086-48f8-a08d-5bb26416b161
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
johb_31_1_1.pdf (3.7 MB)
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| Item type | 文献 / Documents(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-26 | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版社版DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.20738/johb.31.1_1 | |||||
| 言語 | ja | |||||
| 関連名称 | 10.20738/johb.31.1_1 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| タイトル | ||||||
| タイトル | 口腔Biofilm感染症における病原因子と全身に及ぼす影響 | |||||
| 言語 | ja | |||||
| タイトル別表記 | ||||||
| その他のタイトル | Pathogenic Factors in Oral Biofilm Infection and Their Effects on Systemic Diseases | |||||
| 言語 | en | |||||
| 著者 |
湯本, 浩通
× 湯本, 浩通 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Oral infectious diseases, such as dental caries and periodontitis, are caused by oral biofilm, so-called dental plaque. The foundation of the biofilm structure is the extracellular polymeric substances consisting of polysaccharides, toxins, proteins and nucleic acids as well as vesicles, which secrete these components outside of bacterial cells. Among them, extracellular DNA (eDNA) has become increasingly recognized as a key component for biofilm formation and its structural stability. Bacterial histone-like DNA binding protein (HLP), an accessory architectural protein in a variety of bacterial cellular processes due to DNA and mRNA binding capacity, also contributes to the activation of host innate immunity during bacterial infection. Moreover, it has been suggested that vesicles harboring DNA are associated with horizontal gene transfer. In recent two decades, numerous studies regarding the association between oral biofilm infectious diseases and various systemic diseases, such as cardiovascular diseases, atherosclerosis, diabetes mellitus, aspiration pneumonia and autoimmune diseases, have been reported. Besides bacteria, Candida spp., which are frequently implicated in mixed bacterial–fungal infections in humans, can readily form biofilms on the surfaces of denture and cause a variety of infectious diseases ranging from denture stomatitis in denture wearers to life-threatening invasive infections, such as aspiration pneumonia, particularly in immunocompromised and elderly populations. From the viewpoint of biofilm infection, which cause systemic diseases as well as oral infectious diseases, the development of new preventive and therapeutic procedures targeting bacterial-derived pathogenic factors such as eDNA, HLP and vesicle, is expected in future studies. | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 口腔Biofilm | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 病原因子 | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 菌体外DNA | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | DNA結合蛋白 | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 全身疾患 | |||||
| 書誌情報 |
en : Journal of Oral Health and Biosciences 巻 31, 号 1, p. 1-12, 発行日 2018-07-05 |
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| 収録物ID | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 21896682 | |||||
| 出版者 | ||||||
| 出版者 | 四国歯学会 | |||||
| 言語 | ja | |||||
| EID | ||||||
| 識別子 | 343609 | |||||
| 識別子タイプ | URI | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
