| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-18 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.12659/MSM.910608 |
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関連名称 |
10.12659/MSM.910608 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas |
| タイトル別表記 |
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その他のタイトル |
Overexpression of DNMT1 and DNMT3A is associated with aggressive behavior… |
| 著者 |
Ma, Hou-Shi
Wang, Elaine Lu
Xu, Wen-Fei
山田, 正三
吉本, 勝彦
銭, 志栄
Shi, Long
Liu, Li-Li
Li, Xu-Hui
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| 抄録 |
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内容記述 |
BACKGROUND: Alteration of DNA methylation of tumor suppressor genes (TSGs) is one of the most consistent epigenetic changes in human cancers. DNMTs play several important roles in DNA methylation and development of cancers. Regarding DNMTs protein expressions, little is known about the clinical significance and correlation with promoter methylation status of TSGs in human pituitary adenomas.
MATERIAL AND METHODS: We analyzed the protein expression of 3 DNMTs using immunohistochemistry and assessed DNA hypermethylation of RASSF1A, CDH13, CDH1, and CDKN2A (p16) in 63 pituitary adenomas. We examined associations between DNMTs expression and clinicopathological features or promoter methylation status of TSGs.
RESULTS: Overexpression of DNMTs was detected in pituitary adenomas. Frequencies of DNMT1 overexpression were significantly higher in macroadenomas, invasive tumors, and grade III and IV tumors. DNMT3A was frequently detected in invasive tumors and grade IV tumors. In addition, DNMT1 and DNMT3A were frequently detected in high-methylation tumors. Furthermore, in multivariate logistic regression, the significant association between DNMT1 or DNMT3A and high-methylation status persisted after adjusting for clinicopathological features.
CONCLUSIONS: Our findings suggested that tumor overexpression of DNMT1 and DNMT3A is associated with tumor aggressive behavior and high-methylation status in pituitary adenomas. Our data support a possible role of DNMT1 and DNMT3A in TSG promoter methylation leading to pituitary adenoma invasion and suggest that inhibition of DNMTs has the potential to become a new therapeutic approach for invasive pituitary adenoma. |
| キーワード |
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主題 |
Genes, Tumor Suppressor |
| キーワード |
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|
主題 |
Methylation |
| キーワード |
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|
主題 |
Methyltransferases |
| キーワード |
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主題 |
Pituitary Neoplasms |
| 書誌情報 |
en : Medical Science Monitor
巻 24,
p. 4841-4850,
発行日 2018-07-13
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
16433750 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
12341010 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11969504 |
| 出版者 |
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出版者 |
International Scientific Information |
| 権利情報 |
|
|
権利情報 |
© Med Sci Monit, 2018. This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). |
| EID |
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|
識別子 |
340437 |
| 言語 |
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|
言語 |
eng |
medscimonit_24_4841.pdf (229 KB)
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