| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-20 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.chemosphere.2016.12.023 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.chemosphere.2016.12.023 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Cetylpyridinium chloride at sublethal levels increases the susceptibility of rat thymic lymphocytes to oxidative stress |
|
言語 |
en |
| 著者 |
イマイ, ヒロト
キタ, フミヤ
イケスギ, ショウ
アベ, マサミ
ソガベ, シズカ
ニシムラ ダンジョウバラ, ユミコ
| ja |
ニシムラ ダンジョウバラ, ユミコ
|
| ja-Kana |
ニシムラ ダンジョウバラ, ユミコ
|
| en |
Nishimura-Danjobara, Yumiko
|
Search repository
三浦, 哉
小山, 保夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Cetylpyridinium chloride (CPC) is an antimicrobial agent used in many personal care products, with subsequent release into the environment. Since CPC is found at low concentrations in river and municipal wastewater, its influence on wildlife is of concern. Therefore, in this study, we used flow cytometry to examine the effects of sublethal concentrations of CPC on rat thymic lymphocytes in order to characterize the cellular actions of CPC at low concentrations in the presence and absence of H2O2-induced oxidative stress. CPC treatment increased the population of living cells with phosphatidylserine exposed on the outer surface of their plasma membranes (a marker of early stage apoptosis), elevated intracellular Zn2+ levels, and decreased the cellular content of nonprotein thiols. CPC also potentiated the cytotoxicity of H2O2. Our results suggest that, even at environmentally relevant sublethal concentrations, CPC exerts cytotoxic effects under oxidative stress conditions by increasing intracellular Zn2+ concentration and decreasing the cellular content of nonprotein thiols. These findings indicate that, under some in vitro conditions, CPC is bioactive at environmentally relevant concentrations. Therefore, CPC release from personal care products into the environment may need to be regulated to avoid its adverse effects on wildlife. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cetylpyridinium chloride |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
thymocytes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytotoxicity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
zinc |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hydrogen peroxide |
| 書誌情報 |
en : Chemosphere
巻 170,
p. 118-123,
発行日 2016-12-07
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00456535 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00603442 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11523866 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
321746 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
chemos_170_118.pdf (1.09 MB)
