WEKO3
アイテム
Change in plasma membrane potential of rat thymocytes by tert-butylhydroquinone, a food additive : Possible risk on lymphocytes
https://tokushima-u.repo.nii.ac.jp/records/2005148
https://tokushima-u.repo.nii.ac.jp/records/2005148e690c9cd-3848-4a98-ab54-1b12d30c6bb6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
foodchemtox_109_p1_296.pdf (2.2 MB)
|
|
| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2018-07-20 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.fct.2017.09.017 | |||||||||||||||||||||||
| 関連名称 | 10.1016/j.fct.2017.09.017 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Change in plasma membrane potential of rat thymocytes by tert-butylhydroquinone, a food additive : Possible risk on lymphocytes | |||||||||||||||||||||||
| 著者 |
タケダ, マキ
× タケダ, マキ
× オヤマ, ケイスケ
× 亀村, 典生× 金丸, 芳× 湯浅, 恵造× 横井川, 久己男
WEKO
1242
× 小山, 保夫 |
|||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Tertiary butylhydroquinone (TBHQ) is a food additive and has various beneficial actions under in vitro and in vivo experimental conditions. Therefore, it is necessary to collect additional data on the toxicity of TBHQ in order to avoid adverse effects during clinical applications. Changes in plasma membrane potential are associated with changes in physiological functions even in non-excitable cells such as lymphocytes. Thus, compounds that affect membrane potential may modify some lymphocytic functions. The effect of TBHQ on plasma membrane potential was examined in rat thymocytes using flow cytometric techniques. Treatment of rat thymocytes with TBHQ caused hyperpolarization and then depolarization. The TBHQ-induced hyperpolarization was due to the activation of Ca2+-dependent K+ channels. TBHQ elevated intracellular Ca2+ levels. The depolarization by TBHQ was caused by a nonspecific increase in membrane ionic permeability. Both the sustained depolarization and elevation of intracellular Ca2+ level by TBHQ are thought to be adverse for thymocytes because such changes disturb membrane and intracellular signaling. The thymus is most active during neonatal and pre-adolescent periods. If TBHQ exerts adverse actions on thymocytes, it may result in an immunotoxic effect in neonates and adolescents. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | tert-butylhydroquinone | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Food additive | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Membrane potential | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Lymphocytes | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Calcium | |||||||||||||||||||||||
| 書誌情報 |
en : Food and Chemical Toxicology 巻 109, 号 Part 1, p. 296-301, 発行日 2017-09-09 |
|||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 02786915 | |||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA10627174 | |||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11526376 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 333287 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
