| Item type |
文献 / Documents(1) |
| 公開日 |
2018-07-25 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.job.2014.09.001 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.job.2014.09.001 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Basic research and clinical investigations of the neural basis of orofacial pain |
|
言語 |
en |
| 著者 |
松香, 芳三
イワタ, コウイチ
テラヤマ, リュウジ
イマムラ, ヨシキ
マルハマ, コウタロウ
シノダ, マサミチ
ツボイ, ヨシユキ
コンドウ, マサヒロ
ホンダ, クニヤ
カタギリ, アヤノ
スギモト, トモサダ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Trigeminal nerve injury or orofacial inflammation causes severe pain in the orofacial regions innervated by uninjured nerves or uninflamed tissues as well as injured or inflamed tissues. Pathological orofacial pain associated with trigeminal nerve injury or inflammation is difficult to diagnose and treat.
Highlights: To develop appropriate treatments for patients with orofacial pathological pain, various animal models of trigeminal nerve injury or orofacial inflammation have been developed. Further, the possible mechanisms involving the trigeminal ganglion (TG), trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1-C2) have been studied.
Conclusions: 1) Neurotransmitters released from the somata of TG neurons are involved in peripheral sensitization. 2) Neurotransmitter release from TG neurons is decreased by botulinum toxin-type A administration, suggesting that this toxin suppressed neurotransmitter release and alleviated the neuropathic pain-related behavior. 3) Altered states of glial cells and nociceptive neurons, in the Vc and C1-C2 are involved in pathological orofacial pain associated with trigeminal nerve injury or orofacial inflammation. 4) The trigeminal sensory nuclear complex, especially the trigeminal spinal subnucleus oralis, is involved in normal and pathological orofacial pain conditions after peripheral nerve injury. 5) Neuroimaging analyses have suggested functional changes in the central and peripheral nervous systems in neuropathic pain conditions. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Orofacial pathological pain |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nerve injury |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glial cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Trigeminal sensory nuclear complex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Neuroimaging |
| 書誌情報 |
en : Journal of Oral Biosciences
巻 57,
号 1,
p. 27-36,
発行日 2014-10-14
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13490079 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11896386 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12057113 |
| 出版者 |
|
|
出版者 |
The Japanese Association for Oral Biology |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
289008 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
job_57_1_27.pdf (794 KB)
