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Novel amplification mechanism of prions through disrupting sortilin-mediated trafficking
https://tokushima-u.repo.nii.ac.jp/records/2005356
https://tokushima-u.repo.nii.ac.jp/records/20053563a9103f9-d96a-45a6-9620-b2a776e48358
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
prion_11_6_398.pdf (270 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2018-09-21 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1080/19336896.2017.1391435 | |||||||||||
| 関連名称 | 10.1080/19336896.2017.1391435 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| タイトル | ||||||||||||
| タイトル | Novel amplification mechanism of prions through disrupting sortilin-mediated trafficking | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Prion accumulation via sortilin dysfunction | |||||||||||
| 著者 |
坂口, 末廣
× 坂口, 末廣
WEKO
220
× 内山, 圭司 |
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| 抄録 | ||||||||||||
| 内容記述 | Conformational conversion of the cellular prion protein, PrPC, into the abnormally folded isoform of prion protein, PrPSc, which leads to marked accumulation of PrPSc in brains, is a key pathogenic event in prion diseases, a group of fatal neurodegenerative disorders caused by prions. However, the exact mechanism of PrPSc accumulation in prion-infected neurons remains unknown. We recently reported a novel cellular mechanism to support PrPSc accumulation in prion-infected neurons, in which PrPSc itself promotes its accumulation by evading the cellular inhibitory mechanism, which is newly identified in our recent study. We showed that the VPS10P sorting receptor sortilin negatively regulates PrPSc accumulation in prion-infected neurons, by interacting with PrPC and PrPSc and trafficking them to lysosomes for degradation. However, PrPSc stimulated lysosomal degradation of sortilin, disrupting the sortilin-mediated degradation of PrPC and PrPSc and eventually evoking further accumulation of PrPSc in prion-infected neurons. These findings suggest a positive feedback amplification mechanism for PrPSc accumulation in prion-infected neurons. | |||||||||||
| キーワード | ||||||||||||
| 主題 | Prions | |||||||||||
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| 主題 | prion protein | |||||||||||
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| 主題 | protein degradation | |||||||||||
| キーワード | ||||||||||||
| 主題 | lysosome | |||||||||||
| キーワード | ||||||||||||
| 主題 | sortilin | |||||||||||
| キーワード | ||||||||||||
| 主題 | sorting | |||||||||||
| キーワード | ||||||||||||
| 主題 | VPS10P sorting receptor | |||||||||||
| 書誌情報 |
en : Prion 巻 11, 号 6, p. 398-404, 発行日 2017-11-15 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 19336896 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 1933690X | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA12489843 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Taylor & Francis | |||||||||||
| 備考 | ||||||||||||
| 値 | This is an Accepted Manuscript of an article published by Taylor & Francis in Prion on 15/11/2017, available online: http://www.tandfonline.com/10.1080/19336896.2017.1391435. | |||||||||||
| EID | ||||||||||||
| 識別子 | 337786 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
